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Synthesis of 2′-O-methyl-RNAs incorporating a 3-deazaguanine, and UV melting and computational studies on its hybridization properties
2′-O-Methyl-RNAs incorporating 3-deazaguanine (c(3)G) were synthesized by use of N,N-diphenylcarbamoyl and N,N-dimethylaminomethylene as its base protecting groups to suppress sheared-type 5′-GA-3′/5′-GA-3′ tandem mismatched base pairing which requires the N(3) atom. These modified RNAs hybridized m...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636341/ https://www.ncbi.nlm.nih.gov/pubmed/16936323 http://dx.doi.org/10.1093/nar/gkl088 |