Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure

Aberrant activation of the translation initiation machinery is a common property of malignant cells, and is essential for breast carcinoma cells to manifest a malignant phenotype. How does sustained activation of the rate limiting step in protein synthesis so fundamentally alter a cell? In this repo...

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Detalles Bibliográficos
Autores principales: Larsson, Ola, Perlman, David M., Fan, Danhua, Reilly, Cavan S., Peterson, Mark, Dahlgren, Cecilia, Liang, Zicai, Li, Shunan, Polunovsky, Vitaly A., Wahlestedt, Claes, Bitterman, Peter B.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636353/
https://www.ncbi.nlm.nih.gov/pubmed/16936314
http://dx.doi.org/10.1093/nar/gkl558

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