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Chemical synthesis of oligodeoxyribonucleotides containing the Dewar valence isomer of the (6–4) photoproduct and their use in (6–4) photolyase studies

The pyrimidine(6–4)pyrimidone photoproduct, a major UV lesion formed between adjacent pyrimidine bases, is transformed to its Dewar valence isomer upon exposure to UVA/UVB light. We have synthesized a phosphoramidite building block of the Dewar photoproduct formed at the thymidylyl(3′–5′)thymidine s...

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Detalles Bibliográficos
Autores principales: Yamamoto, Junpei, Hitomi, Kenichi, Todo, Takeshi, Iwai, Shigenori
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636357/
https://www.ncbi.nlm.nih.gov/pubmed/16936311
http://dx.doi.org/10.1093/nar/gkl572