Competition for RISC binding predicts in vitro potency of siRNA

Short interfering RNAs (siRNA) guide degradation of target RNA by the RNA-induced silencing complex (RISC). The use of siRNA in animals is limited partially due to the short half-life of siRNAs in tissues. Chemically modified siRNAs are necessary that maintain mRNA degradation activity, but are more...

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Detalles Bibliográficos
Autores principales: Koller, Erich, Propp, Stephanie, Murray, Heather, Lima, Walter, Bhat, Balkrishen, Prakash, Thaza P., Allerson, Charles R., Swayze, Eric E., Marcusson, Eric G., Dean, Nicholas M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636362/
https://www.ncbi.nlm.nih.gov/pubmed/16945958
http://dx.doi.org/10.1093/nar/gkl589

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