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SIR2 modifies histone H4-K16 acetylation and affects superhelicity in the ARS region of plasmid chromatin in Saccharomyces cerevisiae

The null mutation of the SIR2 gene in Saccharomyces cerevisiae has been associated with a series of different phenotypes including loss of transcriptional silencing, genome instability and replicative aging. Thus, the SIR2 gene product is an important constituent of the yeast cell. SIR2 orthologues...

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Detalles Bibliográficos
Autores principales: Chiani, Francesco, Felice, Francesca Di, Camilloni, Giorgio
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636471/
https://www.ncbi.nlm.nih.gov/pubmed/17012273
http://dx.doi.org/10.1093/nar/gkl678