Extrapolation of carcinogenic risk from animal experiments in man.

When estimating the absolute risk of cancer, the shape of the dose--response curve in the region of doses where actual exposure of man occurs is of crucial importance. This shape is equally important for the determination of relative risks, as in the comparison of risks from alternative energy sourc...

Descripción completa

Detalles Bibliográficos
Autores principales: Ehrenberg, L, Holmberg, B
Formato: Texto
Lenguaje:English
Publicado: 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637136/
https://www.ncbi.nlm.nih.gov/pubmed/648489
_version_ 1782130794041442304
author Ehrenberg, L
Holmberg, B
author_facet Ehrenberg, L
Holmberg, B
author_sort Ehrenberg, L
collection PubMed
description When estimating the absolute risk of cancer, the shape of the dose--response curve in the region of doses where actual exposure of man occurs is of crucial importance. This shape is equally important for the determination of relative risks, as in the comparison of risks from alternative energy sources. Experimental and epidemiological studies are, for various reasons, unable to give sufficiently exact information concerning the dose response in the low dose region. Therefore, the discussion concerning dose--response relationships also has to consider biologically reasonable mechanisms for the origin of tumors.
format Text
id pubmed-1637136
institution National Center for Biotechnology Information
language English
publishDate 1978
record_format MEDLINE/PubMed
spelling pubmed-16371362006-11-17 Extrapolation of carcinogenic risk from animal experiments in man. Ehrenberg, L Holmberg, B Environ Health Perspect Research Article When estimating the absolute risk of cancer, the shape of the dose--response curve in the region of doses where actual exposure of man occurs is of crucial importance. This shape is equally important for the determination of relative risks, as in the comparison of risks from alternative energy sources. Experimental and epidemiological studies are, for various reasons, unable to give sufficiently exact information concerning the dose response in the low dose region. Therefore, the discussion concerning dose--response relationships also has to consider biologically reasonable mechanisms for the origin of tumors. 1978-02 /pmc/articles/PMC1637136/ /pubmed/648489 Text en
spellingShingle Research Article
Ehrenberg, L
Holmberg, B
Extrapolation of carcinogenic risk from animal experiments in man.
title Extrapolation of carcinogenic risk from animal experiments in man.
title_full Extrapolation of carcinogenic risk from animal experiments in man.
title_fullStr Extrapolation of carcinogenic risk from animal experiments in man.
title_full_unstemmed Extrapolation of carcinogenic risk from animal experiments in man.
title_short Extrapolation of carcinogenic risk from animal experiments in man.
title_sort extrapolation of carcinogenic risk from animal experiments in man.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637136/
https://www.ncbi.nlm.nih.gov/pubmed/648489
work_keys_str_mv AT ehrenbergl extrapolationofcarcinogenicriskfromanimalexperimentsinman
AT holmbergb extrapolationofcarcinogenicriskfromanimalexperimentsinman

Ejemplares similares