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Symposium on Target Organ Toxicity: cardiovascular system. The epidemiologic approach.

Epidemiological studies rarely provide unequivocal data on the effects of toxic substances on human health. Unlike experimental studies, pertinent variables frequently cannot be controlled and some are often unknown. Nevertheless, these limitations can be dealt with by various facets of an epidemiol...

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Detalles Bibliográficos
Autor principal: Pell, S
Formato: Texto
Lenguaje:English
Publicado: 1978
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637238/
https://www.ncbi.nlm.nih.gov/pubmed/720318
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author Pell, S
author_facet Pell, S
author_sort Pell, S
collection PubMed
description Epidemiological studies rarely provide unequivocal data on the effects of toxic substances on human health. Unlike experimental studies, pertinent variables frequently cannot be controlled and some are often unknown. Nevertheless, these limitations can be dealt with by various facets of an epidemiological investigation. These include, the choice of a study design, selection of controls or comparison populations, evaluation of available data, statistical analysis, and the drawing of appropriate inferences from the data. Among the special problems that might be encountered in studies of the effects of cardiotoxic substances are, difficulties in establishing diagnoses, errors in death certificates, observer errors in electrocardiographic interpretations, and taking into account the effects of various risk factors known to be implicated in the etiology of cardiovascular diseases. In spite of various methodological problems and certain inherent limitations of epidemiological studies, they can, when properly conducted, make significant contributions to knowledge of disease etiology and provide the means of reducing the risk of a disease, even when its etiology is not completely known.
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spelling pubmed-16372382006-11-17 Symposium on Target Organ Toxicity: cardiovascular system. The epidemiologic approach. Pell, S Environ Health Perspect Research Article Epidemiological studies rarely provide unequivocal data on the effects of toxic substances on human health. Unlike experimental studies, pertinent variables frequently cannot be controlled and some are often unknown. Nevertheless, these limitations can be dealt with by various facets of an epidemiological investigation. These include, the choice of a study design, selection of controls or comparison populations, evaluation of available data, statistical analysis, and the drawing of appropriate inferences from the data. Among the special problems that might be encountered in studies of the effects of cardiotoxic substances are, difficulties in establishing diagnoses, errors in death certificates, observer errors in electrocardiographic interpretations, and taking into account the effects of various risk factors known to be implicated in the etiology of cardiovascular diseases. In spite of various methodological problems and certain inherent limitations of epidemiological studies, they can, when properly conducted, make significant contributions to knowledge of disease etiology and provide the means of reducing the risk of a disease, even when its etiology is not completely known. 1978-10 /pmc/articles/PMC1637238/ /pubmed/720318 Text en
spellingShingle Research Article
Pell, S
Symposium on Target Organ Toxicity: cardiovascular system. The epidemiologic approach.
title Symposium on Target Organ Toxicity: cardiovascular system. The epidemiologic approach.
title_full Symposium on Target Organ Toxicity: cardiovascular system. The epidemiologic approach.
title_fullStr Symposium on Target Organ Toxicity: cardiovascular system. The epidemiologic approach.
title_full_unstemmed Symposium on Target Organ Toxicity: cardiovascular system. The epidemiologic approach.
title_short Symposium on Target Organ Toxicity: cardiovascular system. The epidemiologic approach.
title_sort symposium on target organ toxicity: cardiovascular system. the epidemiologic approach.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637238/
https://www.ncbi.nlm.nih.gov/pubmed/720318
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