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Pharmacokinetic models for lipophilic compounds.
In many instances pharmacokinetic modeling offers the best method of interpreting the significance to man of results obtained with laboratory animals but first we must have accurate models for our laboratory animals. A physiological pharmacokinetic model has been used to simulate the disposition of...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
1977
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637340/ https://www.ncbi.nlm.nih.gov/pubmed/413710 |
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author | Matthews, H B Tuey, D B Anderson, M W |
author_facet | Matthews, H B Tuey, D B Anderson, M W |
author_sort | Matthews, H B |
collection | PubMed |
description | In many instances pharmacokinetic modeling offers the best method of interpreting the significance to man of results obtained with laboratory animals but first we must have accurate models for our laboratory animals. A physiological pharmacokinetic model has been used to simulate the disposition of polychlorinated biphenyls (PCBs) in the rat and to extrapolate results obtained with the rat to predict the disposition of PCBs in the mouse. The modeling methods have also been extended to predict the disposition of a polybrominated biphenyl (PBB) in the rat following IV, oral, and multiple oral doses. It is anticipated that with additional experience and work a physiological pharmacokinetic model can be used to predict the disposition of these and other xenobiotics in man. |
format | Text |
id | pubmed-1637340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1977 |
record_format | MEDLINE/PubMed |
spelling | pubmed-16373402006-11-17 Pharmacokinetic models for lipophilic compounds. Matthews, H B Tuey, D B Anderson, M W Environ Health Perspect Research Article In many instances pharmacokinetic modeling offers the best method of interpreting the significance to man of results obtained with laboratory animals but first we must have accurate models for our laboratory animals. A physiological pharmacokinetic model has been used to simulate the disposition of polychlorinated biphenyls (PCBs) in the rat and to extrapolate results obtained with the rat to predict the disposition of PCBs in the mouse. The modeling methods have also been extended to predict the disposition of a polybrominated biphenyl (PBB) in the rat following IV, oral, and multiple oral doses. It is anticipated that with additional experience and work a physiological pharmacokinetic model can be used to predict the disposition of these and other xenobiotics in man. 1977-10 /pmc/articles/PMC1637340/ /pubmed/413710 Text en |
spellingShingle | Research Article Matthews, H B Tuey, D B Anderson, M W Pharmacokinetic models for lipophilic compounds. |
title | Pharmacokinetic models for lipophilic compounds. |
title_full | Pharmacokinetic models for lipophilic compounds. |
title_fullStr | Pharmacokinetic models for lipophilic compounds. |
title_full_unstemmed | Pharmacokinetic models for lipophilic compounds. |
title_short | Pharmacokinetic models for lipophilic compounds. |
title_sort | pharmacokinetic models for lipophilic compounds. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637340/ https://www.ncbi.nlm.nih.gov/pubmed/413710 |
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