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Metallothionein in the extracellular fluids as an index of cadmium toxicity.

In rats injected with 5 micron mole CdCl2/kg, 5 days/week, metallothionein was detected in plasma by gel filtration chromatography as early as four weeks. The mean renal concentration of cadmium was 80 microgram/g. The excretion of cadmium in urine at this time was rather low and amounted to 0.01% o...

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Detalles Bibliográficos
Autores principales: Shaikh, Z A, Hirayama, K
Formato: Texto
Lenguaje:English
Publicado: 1979
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637507/
https://www.ncbi.nlm.nih.gov/pubmed/488041
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author Shaikh, Z A
Hirayama, K
author_facet Shaikh, Z A
Hirayama, K
author_sort Shaikh, Z A
collection PubMed
description In rats injected with 5 micron mole CdCl2/kg, 5 days/week, metallothionein was detected in plasma by gel filtration chromatography as early as four weeks. The mean renal concentration of cadmium was 80 microgram/g. The excretion of cadmium in urine at this time was rather low and amounted to 0.01% of the total dose. The amount of metallothionein in plasma, as determined by 109Cd-binding to the 10,000 molecular weight fraction, increased markedly during week 14. Its excretion in urine, however, did not start until about 10 weeks, when the cadmium concentration in kidney approached a mean value of 212 microgram/g. Signs of renal toxicity were evident from glucosuria and proteinuria which became severe during the next four weeks. The excretion of cadmium in urine increased markedly and the majority of it was in the form of metallothionein. It is suggested that the appearance of metallothionein in plasma and urine can be used as specific indices of cadmium poisoning and that the assay of the protein in these fluids may be useful in screening for excessive cadmium exposure.
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spelling pubmed-16375072006-11-17 Metallothionein in the extracellular fluids as an index of cadmium toxicity. Shaikh, Z A Hirayama, K Environ Health Perspect Research Article In rats injected with 5 micron mole CdCl2/kg, 5 days/week, metallothionein was detected in plasma by gel filtration chromatography as early as four weeks. The mean renal concentration of cadmium was 80 microgram/g. The excretion of cadmium in urine at this time was rather low and amounted to 0.01% of the total dose. The amount of metallothionein in plasma, as determined by 109Cd-binding to the 10,000 molecular weight fraction, increased markedly during week 14. Its excretion in urine, however, did not start until about 10 weeks, when the cadmium concentration in kidney approached a mean value of 212 microgram/g. Signs of renal toxicity were evident from glucosuria and proteinuria which became severe during the next four weeks. The excretion of cadmium in urine increased markedly and the majority of it was in the form of metallothionein. It is suggested that the appearance of metallothionein in plasma and urine can be used as specific indices of cadmium poisoning and that the assay of the protein in these fluids may be useful in screening for excessive cadmium exposure. 1979-02 /pmc/articles/PMC1637507/ /pubmed/488041 Text en
spellingShingle Research Article
Shaikh, Z A
Hirayama, K
Metallothionein in the extracellular fluids as an index of cadmium toxicity.
title Metallothionein in the extracellular fluids as an index of cadmium toxicity.
title_full Metallothionein in the extracellular fluids as an index of cadmium toxicity.
title_fullStr Metallothionein in the extracellular fluids as an index of cadmium toxicity.
title_full_unstemmed Metallothionein in the extracellular fluids as an index of cadmium toxicity.
title_short Metallothionein in the extracellular fluids as an index of cadmium toxicity.
title_sort metallothionein in the extracellular fluids as an index of cadmium toxicity.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637507/
https://www.ncbi.nlm.nih.gov/pubmed/488041
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