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Renal tubular dysfunction and abnormalities of calcium metabolism in cadmium workers

Tubular proteinuria is generally accepted as the critical effect following long-term, low-level exposure to cadmium as seen in an industrial environment. This effect may not be of immediate importance to the health of the individual, but the significance, in terms of long-term morbidity and mortalit...

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Detalles Bibliográficos
Autor principal: Kazantzis, George
Formato: Texto
Lenguaje:English
Publicado: 1979
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637511/
https://www.ncbi.nlm.nih.gov/pubmed/488032
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author Kazantzis, George
author_facet Kazantzis, George
author_sort Kazantzis, George
collection PubMed
description Tubular proteinuria is generally accepted as the critical effect following long-term, low-level exposure to cadmium as seen in an industrial environment. This effect may not be of immediate importance to the health of the individual, but the significance, in terms of long-term morbidity and mortality, of the renal tubular defect of which it is an indicator is not fully understood, and certain sequelae may have remained unrecognized due to inadequate follow-up. Follow-up studies have been performed in nine of 12 workers who were initially investigated in 1962. In six of the men exposures ranged from 28 to 45 years to cadmium sulfide dust and for shorter periods in the earlier years to cadmium oxide fume and dust. These six men had tubular proteinuria when first seen, and this has persisted in the five survivors. All six men had hypercalciuria, and two of them became recurrent stone formers. One man whose urinary calcium excretion later fell to a low level more recently developed vitamin D resistant osteomalacia. In addition, each of the six men had exhibited some, but not all, of a variety of biochemical abnormalities related to other proximal renal tubular defects, and the worker who developed osteomalacia had additional evidence of a distal tubular defect. The five survivors also have evidence of slowly progressive deterioration in glomerular function. Follow-up of this small group has shown that renal tubular dysfunction in cadmium workers may continue symptom-free for long intervals, but in a proportion of cases serious clinical effects may develop after a number of years.
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spelling pubmed-16375112006-11-17 Renal tubular dysfunction and abnormalities of calcium metabolism in cadmium workers Kazantzis, George Environ Health Perspect Articles Tubular proteinuria is generally accepted as the critical effect following long-term, low-level exposure to cadmium as seen in an industrial environment. This effect may not be of immediate importance to the health of the individual, but the significance, in terms of long-term morbidity and mortality, of the renal tubular defect of which it is an indicator is not fully understood, and certain sequelae may have remained unrecognized due to inadequate follow-up. Follow-up studies have been performed in nine of 12 workers who were initially investigated in 1962. In six of the men exposures ranged from 28 to 45 years to cadmium sulfide dust and for shorter periods in the earlier years to cadmium oxide fume and dust. These six men had tubular proteinuria when first seen, and this has persisted in the five survivors. All six men had hypercalciuria, and two of them became recurrent stone formers. One man whose urinary calcium excretion later fell to a low level more recently developed vitamin D resistant osteomalacia. In addition, each of the six men had exhibited some, but not all, of a variety of biochemical abnormalities related to other proximal renal tubular defects, and the worker who developed osteomalacia had additional evidence of a distal tubular defect. The five survivors also have evidence of slowly progressive deterioration in glomerular function. Follow-up of this small group has shown that renal tubular dysfunction in cadmium workers may continue symptom-free for long intervals, but in a proportion of cases serious clinical effects may develop after a number of years. 1979-02 /pmc/articles/PMC1637511/ /pubmed/488032 Text en
spellingShingle Articles
Kazantzis, George
Renal tubular dysfunction and abnormalities of calcium metabolism in cadmium workers
title Renal tubular dysfunction and abnormalities of calcium metabolism in cadmium workers
title_full Renal tubular dysfunction and abnormalities of calcium metabolism in cadmium workers
title_fullStr Renal tubular dysfunction and abnormalities of calcium metabolism in cadmium workers
title_full_unstemmed Renal tubular dysfunction and abnormalities of calcium metabolism in cadmium workers
title_short Renal tubular dysfunction and abnormalities of calcium metabolism in cadmium workers
title_sort renal tubular dysfunction and abnormalities of calcium metabolism in cadmium workers
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637511/
https://www.ncbi.nlm.nih.gov/pubmed/488032
work_keys_str_mv AT kazantzisgeorge renaltubulardysfunctionandabnormalitiesofcalciummetabolismincadmiumworkers