Effect of toxaphene on pyruvic and lactic acid levels in the rat.

Rats were given a single dose of toxaphene (120 mg/kg equilavent to 1/2 LD50) and sacrificed at 1, 5, and 15 days. No alterations of levels of pyruvic or lactic acid in blood plasma were observed. In a second experiment, rats were given 2.4 mg/kg daily and sacrificed at 1, 3, and 6 months, and again...

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Detalles Bibliográficos
Autor principal: Peakall, D B
Formato: Texto
Lenguaje:English
Publicado: 1979
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637716/
https://www.ncbi.nlm.nih.gov/pubmed/446465
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author Peakall, D B
author_facet Peakall, D B
author_sort Peakall, D B
collection PubMed
description Rats were given a single dose of toxaphene (120 mg/kg equilavent to 1/2 LD50) and sacrificed at 1, 5, and 15 days. No alterations of levels of pyruvic or lactic acid in blood plasma were observed. In a second experiment, rats were given 2.4 mg/kg daily and sacrificed at 1, 3, and 6 months, and again no alterations of pyruvic or lactic acid levels were found. It is concluded that observed alterations of the activity of lactic acid dehydrogenase induced by toxaphene do not give rise to physiological changes in unstressed rats.
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spelling pubmed-16377162006-11-17 Effect of toxaphene on pyruvic and lactic acid levels in the rat. Peakall, D B Environ Health Perspect Research Article Rats were given a single dose of toxaphene (120 mg/kg equilavent to 1/2 LD50) and sacrificed at 1, 5, and 15 days. No alterations of levels of pyruvic or lactic acid in blood plasma were observed. In a second experiment, rats were given 2.4 mg/kg daily and sacrificed at 1, 3, and 6 months, and again no alterations of pyruvic or lactic acid levels were found. It is concluded that observed alterations of the activity of lactic acid dehydrogenase induced by toxaphene do not give rise to physiological changes in unstressed rats. 1979-06 /pmc/articles/PMC1637716/ /pubmed/446465 Text en
spellingShingle Research Article
Peakall, D B
Effect of toxaphene on pyruvic and lactic acid levels in the rat.
title Effect of toxaphene on pyruvic and lactic acid levels in the rat.
title_full Effect of toxaphene on pyruvic and lactic acid levels in the rat.
title_fullStr Effect of toxaphene on pyruvic and lactic acid levels in the rat.
title_full_unstemmed Effect of toxaphene on pyruvic and lactic acid levels in the rat.
title_short Effect of toxaphene on pyruvic and lactic acid levels in the rat.
title_sort effect of toxaphene on pyruvic and lactic acid levels in the rat.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637716/
https://www.ncbi.nlm.nih.gov/pubmed/446465
work_keys_str_mv AT peakalldb effectoftoxapheneonpyruvicandlacticacidlevelsintherat

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