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Mental retardation and developmental disabilities influenced by environmental neurotoxic insults.

This paper sets a framework for the discussion of neurotoxicity as a potentially major contributor to the etiology of many types of mental retardation and developmental disabilities. In the past the literatures on developmental neurotoxicology and on mental retardation have evolved independently, ye...

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Autor principal: Schroeder, S R
Formato: Texto
Lenguaje:English
Publicado: 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637836/
https://www.ncbi.nlm.nih.gov/pubmed/10852834
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author Schroeder, S R
author_facet Schroeder, S R
author_sort Schroeder, S R
collection PubMed
description This paper sets a framework for the discussion of neurotoxicity as a potentially major contributor to the etiology of many types of mental retardation and developmental disabilities. In the past the literatures on developmental neurotoxicology and on mental retardation have evolved independently, yet we know that the developing brain is a target for neurotoxicity in the developing central nervous system through many stages of pregnancy as well as during infancy and early childhood. Our definitions and theories of mental retardation and developmental disabilities affect the models of neurotoxicity we espouse. For instance, models of developmental risk in neurotoxicology have guided environmental regulation to reduce the likelihood of neurotoxic effects. On the other hand, models of developmental risk for mental retardation aim not only at primary prevention,but also at secondary and tertiary prevention through early intervention. In the future, dynamic models of neuroplasticity based on the study of gene-brain-behavior relationships are likely to guide our views of developmental neurotoxicology and prevention of mental retardation and other disabilities.
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spelling pubmed-16378362006-11-17 Mental retardation and developmental disabilities influenced by environmental neurotoxic insults. Schroeder, S R Environ Health Perspect Research Article This paper sets a framework for the discussion of neurotoxicity as a potentially major contributor to the etiology of many types of mental retardation and developmental disabilities. In the past the literatures on developmental neurotoxicology and on mental retardation have evolved independently, yet we know that the developing brain is a target for neurotoxicity in the developing central nervous system through many stages of pregnancy as well as during infancy and early childhood. Our definitions and theories of mental retardation and developmental disabilities affect the models of neurotoxicity we espouse. For instance, models of developmental risk in neurotoxicology have guided environmental regulation to reduce the likelihood of neurotoxic effects. On the other hand, models of developmental risk for mental retardation aim not only at primary prevention,but also at secondary and tertiary prevention through early intervention. In the future, dynamic models of neuroplasticity based on the study of gene-brain-behavior relationships are likely to guide our views of developmental neurotoxicology and prevention of mental retardation and other disabilities. 2000-06 /pmc/articles/PMC1637836/ /pubmed/10852834 Text en
spellingShingle Research Article
Schroeder, S R
Mental retardation and developmental disabilities influenced by environmental neurotoxic insults.
title Mental retardation and developmental disabilities influenced by environmental neurotoxic insults.
title_full Mental retardation and developmental disabilities influenced by environmental neurotoxic insults.
title_fullStr Mental retardation and developmental disabilities influenced by environmental neurotoxic insults.
title_full_unstemmed Mental retardation and developmental disabilities influenced by environmental neurotoxic insults.
title_short Mental retardation and developmental disabilities influenced by environmental neurotoxic insults.
title_sort mental retardation and developmental disabilities influenced by environmental neurotoxic insults.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637836/
https://www.ncbi.nlm.nih.gov/pubmed/10852834
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