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Determinants of polybrominated biphenyl serum decay among women in the Michigan PBB cohort.

Accidental contamination of the food chain in Michigan in 1973 with polybrominated biphenyls (PBBs) led to the establishment of a registry of exposed individuals in 1976. Serum was collected and analyzed for PBB at the time of enrollment and for targeted studies in the following years. We used the a...

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Autores principales: Blanck, H M, Marcus, M, Hertzberg, V, Tolbert, P E, Rubin, C, Henderson, A K, Zhang, R H
Formato: Texto
Lenguaje:English
Publicado: 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637888/
https://www.ncbi.nlm.nih.gov/pubmed/10656855
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author Blanck, H M
Marcus, M
Hertzberg, V
Tolbert, P E
Rubin, C
Henderson, A K
Zhang, R H
author_facet Blanck, H M
Marcus, M
Hertzberg, V
Tolbert, P E
Rubin, C
Henderson, A K
Zhang, R H
author_sort Blanck, H M
collection PubMed
description Accidental contamination of the food chain in Michigan in 1973 with polybrominated biphenyls (PBBs) led to the establishment of a registry of exposed individuals in 1976. Serum was collected and analyzed for PBB at the time of enrollment and for targeted studies in the following years. We used the archived PBB data to study the elimination of PBB and to identify factors associated with elimination. A total of 380 women >= 16 years of age who had an initial PBB level of 2 ppb and at least two serum samples drawn when they were not pregnant were included in the analysis. The mean initial PBB level was 20.9 ppb (median 4) and mean time between the first and last measurement was 4.2 years (range 0.5-11.1). PBB was assumed to reach equilibrium in the body before substantial amounts were eliminated and before the first serum measurements were taken; therefore, the entire body was modeled as a single compartment for PBB with exponential decay. Subject-specific decay rate estimates were regressed on predictor variables including initial age, body mass index (BMI), smoking history, breast-feeding duration, and parity. In women with an initial PBB level < 10 ppb, the median half-life was 12.9 years; in those with > 10 ppb, the median half-life was 28.7 years. Decay was significantly slower among women with an initial BMI at or above the median (BMI >= 23). The calculated half-life values are estimates of decay and can be used to estimate body burden of PBB at various points in time other than at the time of serum collection.
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spelling pubmed-16378882006-11-17 Determinants of polybrominated biphenyl serum decay among women in the Michigan PBB cohort. Blanck, H M Marcus, M Hertzberg, V Tolbert, P E Rubin, C Henderson, A K Zhang, R H Environ Health Perspect Research Article Accidental contamination of the food chain in Michigan in 1973 with polybrominated biphenyls (PBBs) led to the establishment of a registry of exposed individuals in 1976. Serum was collected and analyzed for PBB at the time of enrollment and for targeted studies in the following years. We used the archived PBB data to study the elimination of PBB and to identify factors associated with elimination. A total of 380 women >= 16 years of age who had an initial PBB level of 2 ppb and at least two serum samples drawn when they were not pregnant were included in the analysis. The mean initial PBB level was 20.9 ppb (median 4) and mean time between the first and last measurement was 4.2 years (range 0.5-11.1). PBB was assumed to reach equilibrium in the body before substantial amounts were eliminated and before the first serum measurements were taken; therefore, the entire body was modeled as a single compartment for PBB with exponential decay. Subject-specific decay rate estimates were regressed on predictor variables including initial age, body mass index (BMI), smoking history, breast-feeding duration, and parity. In women with an initial PBB level < 10 ppb, the median half-life was 12.9 years; in those with > 10 ppb, the median half-life was 28.7 years. Decay was significantly slower among women with an initial BMI at or above the median (BMI >= 23). The calculated half-life values are estimates of decay and can be used to estimate body burden of PBB at various points in time other than at the time of serum collection. 2000-02 /pmc/articles/PMC1637888/ /pubmed/10656855 Text en
spellingShingle Research Article
Blanck, H M
Marcus, M
Hertzberg, V
Tolbert, P E
Rubin, C
Henderson, A K
Zhang, R H
Determinants of polybrominated biphenyl serum decay among women in the Michigan PBB cohort.
title Determinants of polybrominated biphenyl serum decay among women in the Michigan PBB cohort.
title_full Determinants of polybrominated biphenyl serum decay among women in the Michigan PBB cohort.
title_fullStr Determinants of polybrominated biphenyl serum decay among women in the Michigan PBB cohort.
title_full_unstemmed Determinants of polybrominated biphenyl serum decay among women in the Michigan PBB cohort.
title_short Determinants of polybrominated biphenyl serum decay among women in the Michigan PBB cohort.
title_sort determinants of polybrominated biphenyl serum decay among women in the michigan pbb cohort.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637888/
https://www.ncbi.nlm.nih.gov/pubmed/10656855
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