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Clinical trials in cancer research.
This is a review paper which gives a discussion of various aspects of clinical trials in cancer research. Since the conduct of the first randomized controlled clinical trial in cancer patients in the mid-1950's, substantial progress has been made in the utilization of the clinical trial techniq...
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Formato: | Texto |
Lenguaje: | English |
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1979
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637924/ https://www.ncbi.nlm.nih.gov/pubmed/232043 |
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author | Gehan, E A |
author_facet | Gehan, E A |
author_sort | Gehan, E A |
collection | PubMed |
description | This is a review paper which gives a discussion of various aspects of clinical trials in cancer research. Since the conduct of the first randomized controlled clinical trial in cancer patients in the mid-1950's, substantial progress has been made in the utilization of the clinical trial technique for the evaluation of therapeutic efficiacy. The important elements of a protocol are given with some discussion of items to be considered in designing a protocol. The types of clinical trial (phase I, II, III) are defined, and the place of each phase of study in the context of the search for new treatments is delineated. A comprehensive discussion is given of the elements in the comparative clinical trial (phase III), including objectives, consierations in planning (comparability of treatment groups stratification of patients, feasibility and size of study, and prospective versus retrospective studies). Brief descriptions are given of designs for comparative clinical trials and a trial in oat cell lung carcinoma is discussed in some detail. Finally, some comments and references are given concerning the analysis of clinical trials. |
format | Text |
id | pubmed-1637924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1979 |
record_format | MEDLINE/PubMed |
spelling | pubmed-16379242006-11-17 Clinical trials in cancer research. Gehan, E A Environ Health Perspect Research Article This is a review paper which gives a discussion of various aspects of clinical trials in cancer research. Since the conduct of the first randomized controlled clinical trial in cancer patients in the mid-1950's, substantial progress has been made in the utilization of the clinical trial technique for the evaluation of therapeutic efficiacy. The important elements of a protocol are given with some discussion of items to be considered in designing a protocol. The types of clinical trial (phase I, II, III) are defined, and the place of each phase of study in the context of the search for new treatments is delineated. A comprehensive discussion is given of the elements in the comparative clinical trial (phase III), including objectives, consierations in planning (comparability of treatment groups stratification of patients, feasibility and size of study, and prospective versus retrospective studies). Brief descriptions are given of designs for comparative clinical trials and a trial in oat cell lung carcinoma is discussed in some detail. Finally, some comments and references are given concerning the analysis of clinical trials. 1979-10 /pmc/articles/PMC1637924/ /pubmed/232043 Text en |
spellingShingle | Research Article Gehan, E A Clinical trials in cancer research. |
title | Clinical trials in cancer research. |
title_full | Clinical trials in cancer research. |
title_fullStr | Clinical trials in cancer research. |
title_full_unstemmed | Clinical trials in cancer research. |
title_short | Clinical trials in cancer research. |
title_sort | clinical trials in cancer research. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637924/ https://www.ncbi.nlm.nih.gov/pubmed/232043 |
work_keys_str_mv | AT gehanea clinicaltrialsincancerresearch |