Chromium(III)-induced 8-hydroxydeoxyguanosine in DNA and its reduction by antioxidants: comparative effects of melatonin, ascorbate, and vitamin E.

Chromium compounds are well documented carcinogens. Cr(III) is more reactive than Cr(VI) toward DNA under in vitro conditions. In the present study, we investigated the ability of Cr(III) to induce oxidative DNA damage by examining the formation of 8-hydroxydeoxyguanosine (8-OH-dG) in calf thymus DN...

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Detalles Bibliográficos
Autores principales: Qi, W, Reiter, R J, Tan, D X, Garcia, J J, Manchester, L C, Karbownik, M, Calvo, J R
Formato: Texto
Lenguaje:English
Publicado: 2000
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1638051/
https://www.ncbi.nlm.nih.gov/pubmed/10811565

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