C766T low-density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and susceptibility to breast cancer

BACKGROUND: Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor with an important role in regulating the activity of proteinases in extracellular matrix. Several studies have also described its role in intracellular signaling. Previous studies showed tha...

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Autores principales: Beneš, Petr, Jurajda, Michal, Žaloudík, Jan, Izakovičová-Hollá, Lydie, Vácha, Jiří
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165006/
https://www.ncbi.nlm.nih.gov/pubmed/12793904
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author Beneš, Petr
Jurajda, Michal
Žaloudík, Jan
Izakovičová-Hollá, Lydie
Vácha, Jiří
author_facet Beneš, Petr
Jurajda, Michal
Žaloudík, Jan
Izakovičová-Hollá, Lydie
Vácha, Jiří
author_sort Beneš, Petr
collection PubMed
description BACKGROUND: Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor with an important role in regulating the activity of proteinases in extracellular matrix. Several studies have also described its role in intracellular signaling. Previous studies showed that the expression of LRP1 is related to invasiveness of cancer cells. However, recent data on LRP1 suggest that this receptor can also be involved in tumor establishment and progression. METHODS: We investigated an association between the C766T polymorphism of the third exon of the LRP1 gene and breast cancer in a sample of women of Caucasian origin. Allele and genotype frequencies of this polymorphism were assessed in 164 women with breast cancer and in 183 age-compatible women without a history of any cancer disease. RESULTS: An increase in LRP1 T allele frequency in subjects with breast cancer was observed compared with controls (0.21 versus 0.15, P = 0.01963). A significant excess of genotypes with the T allele (homozygotes plus heterozygotes) was also observed (odds ratio 1.743, 95% confidence interval 1.112–2.732). CONCLUSION: The T allele of the C766T polymorphism in the LRP1 gene is associated with an increased risk of breast cancer development in women of Caucasian origin.
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spelling pubmed-1650062003-07-12 C766T low-density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and susceptibility to breast cancer Beneš, Petr Jurajda, Michal Žaloudík, Jan Izakovičová-Hollá, Lydie Vácha, Jiří Breast Cancer Res Research Article BACKGROUND: Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor with an important role in regulating the activity of proteinases in extracellular matrix. Several studies have also described its role in intracellular signaling. Previous studies showed that the expression of LRP1 is related to invasiveness of cancer cells. However, recent data on LRP1 suggest that this receptor can also be involved in tumor establishment and progression. METHODS: We investigated an association between the C766T polymorphism of the third exon of the LRP1 gene and breast cancer in a sample of women of Caucasian origin. Allele and genotype frequencies of this polymorphism were assessed in 164 women with breast cancer and in 183 age-compatible women without a history of any cancer disease. RESULTS: An increase in LRP1 T allele frequency in subjects with breast cancer was observed compared with controls (0.21 versus 0.15, P = 0.01963). A significant excess of genotypes with the T allele (homozygotes plus heterozygotes) was also observed (odds ratio 1.743, 95% confidence interval 1.112–2.732). CONCLUSION: The T allele of the C766T polymorphism in the LRP1 gene is associated with an increased risk of breast cancer development in women of Caucasian origin. BioMed Central 2003 2003-03-14 /pmc/articles/PMC165006/ /pubmed/12793904 Text en Copyright © 2003 Beneš et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Research Article
Beneš, Petr
Jurajda, Michal
Žaloudík, Jan
Izakovičová-Hollá, Lydie
Vácha, Jiří
C766T low-density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and susceptibility to breast cancer
title C766T low-density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and susceptibility to breast cancer
title_full C766T low-density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and susceptibility to breast cancer
title_fullStr C766T low-density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and susceptibility to breast cancer
title_full_unstemmed C766T low-density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and susceptibility to breast cancer
title_short C766T low-density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and susceptibility to breast cancer
title_sort c766t low-density lipoprotein receptor-related protein 1 (lrp1) gene polymorphism and susceptibility to breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165006/
https://www.ncbi.nlm.nih.gov/pubmed/12793904
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