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The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer

Testosterone binds to the androgen receptor in target tissue to mediate its effects. Variations in testosterone levels and androgen receptor activity may play a role in the etiology of breast cancer. Here, we review the epidemiologic evidence linking endogenous testosterone to breast cancer risk. Pa...

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Detalles Bibliográficos
Autores principales: Lillie, Elizabeth O, Bernstein, Leslie, Ursin, Giske
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165007/
https://www.ncbi.nlm.nih.gov/pubmed/12793900
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author Lillie, Elizabeth O
Bernstein, Leslie
Ursin, Giske
author_facet Lillie, Elizabeth O
Bernstein, Leslie
Ursin, Giske
author_sort Lillie, Elizabeth O
collection PubMed
description Testosterone binds to the androgen receptor in target tissue to mediate its effects. Variations in testosterone levels and androgen receptor activity may play a role in the etiology of breast cancer. Here, we review the epidemiologic evidence linking endogenous testosterone to breast cancer risk. Paradoxically, results from observational studies that have examined polymorphisms in the androgen receptor suggest that the low-activity androgen receptor increases breast cancer risk. We review the quality of this evidence and conclude with a discussion of how the androgen receptor and testosterone results coincide.
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spelling pubmed-1650072003-07-12 The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer Lillie, Elizabeth O Bernstein, Leslie Ursin, Giske Breast Cancer Res Review Testosterone binds to the androgen receptor in target tissue to mediate its effects. Variations in testosterone levels and androgen receptor activity may play a role in the etiology of breast cancer. Here, we review the epidemiologic evidence linking endogenous testosterone to breast cancer risk. Paradoxically, results from observational studies that have examined polymorphisms in the androgen receptor suggest that the low-activity androgen receptor increases breast cancer risk. We review the quality of this evidence and conclude with a discussion of how the androgen receptor and testosterone results coincide. BioMed Central 2003 2003-04-02 /pmc/articles/PMC165007/ /pubmed/12793900 Text en Copyright © 2003 BioMed Central Ltd
spellingShingle Review
Lillie, Elizabeth O
Bernstein, Leslie
Ursin, Giske
The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer
title The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer
title_full The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer
title_fullStr The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer
title_full_unstemmed The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer
title_short The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer
title_sort role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165007/
https://www.ncbi.nlm.nih.gov/pubmed/12793900
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