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Aggrecanases and cartilage matrix degradation
The loss of extracellular matrix macromolecules from the cartilage results in serious impairment of joint function. Metalloproteinases called 'aggrecanases' that cleave the Glu(373)–Ala(374 )bond of the aggrecan core protein play a key role in the early stages of cartilage destruction in r...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165039/ https://www.ncbi.nlm.nih.gov/pubmed/12718749 |