Autoinsertion of soluble oligomers of Alzheimer's Aβ(1–42) peptide into cholesterol-containing membranes is accompanied by relocation of the sterol towards the bilayer surface

BACKGROUND: Soluble Alzheimer's Aβ oligomers autoinsert into neuronal cell membranes, contributing to the pathology of Alzheimer's Disease (AD), and elevated serum cholesterol is a risk factor for AD, but the reason is unknown. We investigated potential connections between these two observ...

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Detalles Bibliográficos
Autores principales: Ashley, Richard H, Harroun, Thad A, Hauss, Thomas, Breen, Kieran C, Bradshaw, Jeremy P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1657013/
https://www.ncbi.nlm.nih.gov/pubmed/17052343
http://dx.doi.org/10.1186/1472-6807-6-21

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