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Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress

The purpose of this present study was to evaluate the serum levels of ET-1 and TGF-β in the newborns with respiratory distress. In this study, newborns with respiratory distress hospitalized into the Newborn Intensive Care Unit were included. The highest values of ET-1 and TGF-β were obtained from n...

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Autores principales: Benzer, Derya, Aygun, A. Denizmen, Godekmerdan, Ahmet, (Citak) Kurt, A. Nese, Akarsu, Saadet, Yilmaz, Erdal
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1657074/
https://www.ncbi.nlm.nih.gov/pubmed/17392579
http://dx.doi.org/10.1155/MI/2006/85432
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author Benzer, Derya
Aygun, A. Denizmen
Godekmerdan, Ahmet
(Citak) Kurt, A. Nese
Akarsu, Saadet
Yilmaz, Erdal
author_facet Benzer, Derya
Aygun, A. Denizmen
Godekmerdan, Ahmet
(Citak) Kurt, A. Nese
Akarsu, Saadet
Yilmaz, Erdal
author_sort Benzer, Derya
collection PubMed
description The purpose of this present study was to evaluate the serum levels of ET-1 and TGF-β in the newborns with respiratory distress. In this study, newborns with respiratory distress hospitalized into the Newborn Intensive Care Unit were included. The highest values of ET-1 and TGF-β were obtained from newborns with diagnosis as meconium aspiration syndrome (5.70 ± 5.87 pg/mL and 3.75 ± 1.94 pg/mL, resp) in the sample obtained in the first six hours after birth, and these are statistically different from control group (P < .05). Also, same results were obtained for newborns with respiratory distress syndrome (3.37 ± 1.59 pg/mL and 2.05 ± 0.98 pg/mL, resp). After oxygen treatment, ET-1 values obtained in the first six hours of life were decreased regularly in the following days (P < .05). In the differentiating diagnosis of the respiratory distress of newborns, the investigation of ET-1 and TGF-β levels is meaningful. The ET-1 levels investigated in the first six hours is more useful in determining the prognosis, and repeating ET-1 levels in the following days is more meaningful to determine clinical response.
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spelling pubmed-16570742006-12-04 Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress Benzer, Derya Aygun, A. Denizmen Godekmerdan, Ahmet (Citak) Kurt, A. Nese Akarsu, Saadet Yilmaz, Erdal Mediators Inflamm Research Communication The purpose of this present study was to evaluate the serum levels of ET-1 and TGF-β in the newborns with respiratory distress. In this study, newborns with respiratory distress hospitalized into the Newborn Intensive Care Unit were included. The highest values of ET-1 and TGF-β were obtained from newborns with diagnosis as meconium aspiration syndrome (5.70 ± 5.87 pg/mL and 3.75 ± 1.94 pg/mL, resp) in the sample obtained in the first six hours after birth, and these are statistically different from control group (P < .05). Also, same results were obtained for newborns with respiratory distress syndrome (3.37 ± 1.59 pg/mL and 2.05 ± 0.98 pg/mL, resp). After oxygen treatment, ET-1 values obtained in the first six hours of life were decreased regularly in the following days (P < .05). In the differentiating diagnosis of the respiratory distress of newborns, the investigation of ET-1 and TGF-β levels is meaningful. The ET-1 levels investigated in the first six hours is more useful in determining the prognosis, and repeating ET-1 levels in the following days is more meaningful to determine clinical response. Hindawi Publishing Corporation 2006 2006-09-20 /pmc/articles/PMC1657074/ /pubmed/17392579 http://dx.doi.org/10.1155/MI/2006/85432 Text en Copyright © 2006 Derya Benzer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Communication
Benzer, Derya
Aygun, A. Denizmen
Godekmerdan, Ahmet
(Citak) Kurt, A. Nese
Akarsu, Saadet
Yilmaz, Erdal
Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress
title Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress
title_full Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress
title_fullStr Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress
title_full_unstemmed Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress
title_short Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress
title_sort serum endothelin-1 and transforming growth factor-β levels in the newborns with respiratory distress
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1657074/
https://www.ncbi.nlm.nih.gov/pubmed/17392579
http://dx.doi.org/10.1155/MI/2006/85432
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