IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment

In colorectal cancer insulin-like growth factor II (IGF-II) is frequently overexpressed. To evaluate, whether IGF-II affects different stages of tumorigenesis, we induced neoplastic alterations in the colon of wild-type and IGF-II transgenic mice using 1,2-dimethylhydrazine (DMH). Aberrant crypt foc...

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Detalles Bibliográficos
Autores principales: Diehl, Daniela, Oesterle, Doris, Elmlinger, Martin W, Hoeflich, Andreas, Wolf, Eckhard, Lahm, Harald
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1660565/
https://www.ncbi.nlm.nih.gov/pubmed/17118177
http://dx.doi.org/10.1186/1477-3163-5-24

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