Cargando…
A review of daptomycin for injection (Cubicin) in the treatment of complicated skin and skin structure infections
Daptomycin is a novel bactericidal antibiotic with excellent activity against gram-positive organisms. It is a large cyclic lipopeptide with a unique mechanism of action. Daptomycin is given once a day and is renally cleared, requiring dose adjustment in patients with impaired renal function. Unfort...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2006
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1661656/ https://www.ncbi.nlm.nih.gov/pubmed/18360590 |
_version_ | 1782131059765280768 |
---|---|
author | Shoemaker, D Matthew Simou, Jikerkhoun Roland, William E |
author_facet | Shoemaker, D Matthew Simou, Jikerkhoun Roland, William E |
author_sort | Shoemaker, D Matthew |
collection | PubMed |
description | Daptomycin is a novel bactericidal antibiotic with excellent activity against gram-positive organisms. It is a large cyclic lipopeptide with a unique mechanism of action. Daptomycin is given once a day and is renally cleared, requiring dose adjustment in patients with impaired renal function. Unfortunately, there have been case reports of resistant gram-positive organisms. Daptomycin is generally well tolerated, though myopathy has been reported. 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors should be stopped in patients on daptomycin. Daptomycin shows promise in experimental models of endocarditis, meningitis, ventriculitis, and peritonitis, and is currently approved for use in skin and soft-tissue infections. Daptomycin is a welcome newcomer to the gram-positive antimicrobial arsenal. |
format | Text |
id | pubmed-1661656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-16616562008-03-21 A review of daptomycin for injection (Cubicin) in the treatment of complicated skin and skin structure infections Shoemaker, D Matthew Simou, Jikerkhoun Roland, William E Ther Clin Risk Manag Review Daptomycin is a novel bactericidal antibiotic with excellent activity against gram-positive organisms. It is a large cyclic lipopeptide with a unique mechanism of action. Daptomycin is given once a day and is renally cleared, requiring dose adjustment in patients with impaired renal function. Unfortunately, there have been case reports of resistant gram-positive organisms. Daptomycin is generally well tolerated, though myopathy has been reported. 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors should be stopped in patients on daptomycin. Daptomycin shows promise in experimental models of endocarditis, meningitis, ventriculitis, and peritonitis, and is currently approved for use in skin and soft-tissue infections. Daptomycin is a welcome newcomer to the gram-positive antimicrobial arsenal. Dove Medical Press 2006-06 2006-06 /pmc/articles/PMC1661656/ /pubmed/18360590 Text en © 2006 Dove Medical Press Limited. All rights reserved |
spellingShingle | Review Shoemaker, D Matthew Simou, Jikerkhoun Roland, William E A review of daptomycin for injection (Cubicin) in the treatment of complicated skin and skin structure infections |
title | A review of daptomycin for injection (Cubicin) in the treatment of complicated skin and skin structure infections |
title_full | A review of daptomycin for injection (Cubicin) in the treatment of complicated skin and skin structure infections |
title_fullStr | A review of daptomycin for injection (Cubicin) in the treatment of complicated skin and skin structure infections |
title_full_unstemmed | A review of daptomycin for injection (Cubicin) in the treatment of complicated skin and skin structure infections |
title_short | A review of daptomycin for injection (Cubicin) in the treatment of complicated skin and skin structure infections |
title_sort | review of daptomycin for injection (cubicin) in the treatment of complicated skin and skin structure infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1661656/ https://www.ncbi.nlm.nih.gov/pubmed/18360590 |
work_keys_str_mv | AT shoemakerdmatthew areviewofdaptomycinforinjectioncubicininthetreatmentofcomplicatedskinandskinstructureinfections AT simoujikerkhoun areviewofdaptomycinforinjectioncubicininthetreatmentofcomplicatedskinandskinstructureinfections AT rolandwilliame areviewofdaptomycinforinjectioncubicininthetreatmentofcomplicatedskinandskinstructureinfections AT shoemakerdmatthew reviewofdaptomycinforinjectioncubicininthetreatmentofcomplicatedskinandskinstructureinfections AT simoujikerkhoun reviewofdaptomycinforinjectioncubicininthetreatmentofcomplicatedskinandskinstructureinfections AT rolandwilliame reviewofdaptomycinforinjectioncubicininthetreatmentofcomplicatedskinandskinstructureinfections |