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Robustness and Fragility in Immunosenescence
We construct a model to study tradeoffs associated with aging in the adaptive immune system, focusing on cumulative effects of replacing naive cells with memory cells. Binding affinities are characterized by a stochastic shape space model. System loss arising from an individual infection is associat...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1664698/ https://www.ncbi.nlm.nih.gov/pubmed/17121459 http://dx.doi.org/10.1371/journal.pcbi.0020160 |