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Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study
BACKGROUND: The transcription factor 7-like 2 (TCF7L2) is a critical component of the Wnt/β-catenin pathway. Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC and cyclin D. Genetic alterations in TCF7L2 may therefore affect cancer risk...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665524/ https://www.ncbi.nlm.nih.gov/pubmed/17109766 http://dx.doi.org/10.1186/1471-2407-6-268 |
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author | Burwinkel, Barbara Shanmugam, Kalai S Hemminki, Kari Meindl, Alfons Schmutzler, Rita K Sutter, Christian Wappenschmidt, Barbara Kiechle, Marion Bartram, Claus R Frank, Bernd |
author_facet | Burwinkel, Barbara Shanmugam, Kalai S Hemminki, Kari Meindl, Alfons Schmutzler, Rita K Sutter, Christian Wappenschmidt, Barbara Kiechle, Marion Bartram, Claus R Frank, Bernd |
author_sort | Burwinkel, Barbara |
collection | PubMed |
description | BACKGROUND: The transcription factor 7-like 2 (TCF7L2) is a critical component of the Wnt/β-catenin pathway. Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC and cyclin D. Genetic alterations in TCF7L2 may therefore affect cancer risk. Recently, TCF7L2 variants, including the microsatellite marker DG10S478 and the nearly perfectly linked SNP rs12233372, were identified to associate with type 2 diabetes. METHODS: We investigated the effect of the TCF7L2 rs12255372 variant on familial breast cancer (BC) risk by means of TaqMan allelic discrimination, analyzing BRCA1/2 mutation-negative index patients of 592 German BC families and 735 control individuals. RESULTS: The T allele of rs12255372 showed an association with borderline significance (OR = 1.19, 95% C.I. = 1.01-1.42, P = 0.04), and the Cochran-Armitage test for trend revealed an allele dose-dependent association of rs12255372 with BC risk (P(trend )= 0.04). CONCLUSION: Our results suggest a possible influence of TCF7L2 rs12255372 on the risk of familial BC. |
format | Text |
id | pubmed-1665524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-16655242006-11-30 Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study Burwinkel, Barbara Shanmugam, Kalai S Hemminki, Kari Meindl, Alfons Schmutzler, Rita K Sutter, Christian Wappenschmidt, Barbara Kiechle, Marion Bartram, Claus R Frank, Bernd BMC Cancer Research Article BACKGROUND: The transcription factor 7-like 2 (TCF7L2) is a critical component of the Wnt/β-catenin pathway. Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC and cyclin D. Genetic alterations in TCF7L2 may therefore affect cancer risk. Recently, TCF7L2 variants, including the microsatellite marker DG10S478 and the nearly perfectly linked SNP rs12233372, were identified to associate with type 2 diabetes. METHODS: We investigated the effect of the TCF7L2 rs12255372 variant on familial breast cancer (BC) risk by means of TaqMan allelic discrimination, analyzing BRCA1/2 mutation-negative index patients of 592 German BC families and 735 control individuals. RESULTS: The T allele of rs12255372 showed an association with borderline significance (OR = 1.19, 95% C.I. = 1.01-1.42, P = 0.04), and the Cochran-Armitage test for trend revealed an allele dose-dependent association of rs12255372 with BC risk (P(trend )= 0.04). CONCLUSION: Our results suggest a possible influence of TCF7L2 rs12255372 on the risk of familial BC. BioMed Central 2006-11-17 /pmc/articles/PMC1665524/ /pubmed/17109766 http://dx.doi.org/10.1186/1471-2407-6-268 Text en Copyright © 2006 Burwinkel et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Burwinkel, Barbara Shanmugam, Kalai S Hemminki, Kari Meindl, Alfons Schmutzler, Rita K Sutter, Christian Wappenschmidt, Barbara Kiechle, Marion Bartram, Claus R Frank, Bernd Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study |
title | Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study |
title_full | Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study |
title_fullStr | Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study |
title_full_unstemmed | Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study |
title_short | Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study |
title_sort | transcription factor 7-like 2 (tcf7l2) variant is associated with familial breast cancer risk: a case-control study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665524/ https://www.ncbi.nlm.nih.gov/pubmed/17109766 http://dx.doi.org/10.1186/1471-2407-6-268 |
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