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‘LeishMan’ topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani
The active site tyrosine residue of all monomeric type IB topoisomerases resides in the C-terminal domain of the enzyme. Leishmania donovani, possesses unusual heterodimeric type IB topoisomerase. The small subunit harbors the catalytic tyrosine within the SKXXY motif. To explore the functional rela...
Autores principales: | Ganguly, Agneyo, Das, Benu Brata, Sen, Nilkantha, Roy, Amit, Dasgupta, Somdeb Bose, Majumder, Hemanta K. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1669778/ https://www.ncbi.nlm.nih.gov/pubmed/17098934 http://dx.doi.org/10.1093/nar/gkl829 |
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