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Histological analysis of the effects of a static magnetic field on bone healing process in rat femurs

BACKGROUND: The aim of this study was to investigate, in vivo, the quality of bone healing under the effect of a static magnetic field, arranged inside the body. METHODS: A metallic device was developed, consisting of two stainless steel washers attached to the bone structure with titanium screws. T...

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Autores principales: Puricelli, Edela, Ulbrich, Lucienne M, Ponzoni, Deise, Filho, João Julio da Cunha
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1675997/
https://www.ncbi.nlm.nih.gov/pubmed/17125508
http://dx.doi.org/10.1186/1746-160X-2-43
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author Puricelli, Edela
Ulbrich, Lucienne M
Ponzoni, Deise
Filho, João Julio da Cunha
author_facet Puricelli, Edela
Ulbrich, Lucienne M
Ponzoni, Deise
Filho, João Julio da Cunha
author_sort Puricelli, Edela
collection PubMed
description BACKGROUND: The aim of this study was to investigate, in vivo, the quality of bone healing under the effect of a static magnetic field, arranged inside the body. METHODS: A metallic device was developed, consisting of two stainless steel washers attached to the bone structure with titanium screws. Twenty-one Wistar rats (Rattus novergicus albinus) were used in this randomized experimental study. Each experimental group had five rats, and two animals were included as control for each of the groups. A pair of metal device was attached to the left femur of each animal, lightly touching a surgically created bone cavity. In the experimental groups, washers were placed in that way that they allowed mutual attraction forces. In the control group, surgery was performed but washers, screws or instruments were not magnetized. The animals were sacrificed 15, 45 and 60 days later, and the samples were submitted to histological analysis. RESULTS: On days 15 and 45 after the surgical procedure, bone healing was more effective in the experimental group as compared to control animals. Sixty days after the surgical procedure, marked bone neoformation was observed in the test group, suggesting the existence of continued magnetic stimulation during the experiment. CONCLUSION: The magnetic stainless steel device, buried in the bone, in vivo, resulted in increased efficiency of the experimental bone healing process.
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spelling pubmed-16759972006-12-01 Histological analysis of the effects of a static magnetic field on bone healing process in rat femurs Puricelli, Edela Ulbrich, Lucienne M Ponzoni, Deise Filho, João Julio da Cunha Head Face Med Research BACKGROUND: The aim of this study was to investigate, in vivo, the quality of bone healing under the effect of a static magnetic field, arranged inside the body. METHODS: A metallic device was developed, consisting of two stainless steel washers attached to the bone structure with titanium screws. Twenty-one Wistar rats (Rattus novergicus albinus) were used in this randomized experimental study. Each experimental group had five rats, and two animals were included as control for each of the groups. A pair of metal device was attached to the left femur of each animal, lightly touching a surgically created bone cavity. In the experimental groups, washers were placed in that way that they allowed mutual attraction forces. In the control group, surgery was performed but washers, screws or instruments were not magnetized. The animals were sacrificed 15, 45 and 60 days later, and the samples were submitted to histological analysis. RESULTS: On days 15 and 45 after the surgical procedure, bone healing was more effective in the experimental group as compared to control animals. Sixty days after the surgical procedure, marked bone neoformation was observed in the test group, suggesting the existence of continued magnetic stimulation during the experiment. CONCLUSION: The magnetic stainless steel device, buried in the bone, in vivo, resulted in increased efficiency of the experimental bone healing process. BioMed Central 2006-11-24 /pmc/articles/PMC1675997/ /pubmed/17125508 http://dx.doi.org/10.1186/1746-160X-2-43 Text en Copyright © 2006 Puricelli et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Puricelli, Edela
Ulbrich, Lucienne M
Ponzoni, Deise
Filho, João Julio da Cunha
Histological analysis of the effects of a static magnetic field on bone healing process in rat femurs
title Histological analysis of the effects of a static magnetic field on bone healing process in rat femurs
title_full Histological analysis of the effects of a static magnetic field on bone healing process in rat femurs
title_fullStr Histological analysis of the effects of a static magnetic field on bone healing process in rat femurs
title_full_unstemmed Histological analysis of the effects of a static magnetic field on bone healing process in rat femurs
title_short Histological analysis of the effects of a static magnetic field on bone healing process in rat femurs
title_sort histological analysis of the effects of a static magnetic field on bone healing process in rat femurs
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1675997/
https://www.ncbi.nlm.nih.gov/pubmed/17125508
http://dx.doi.org/10.1186/1746-160X-2-43
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