Synthetic protein–protein interaction domains created by shuffling Cys(2)His(2) zinc-fingers

Cys(2)His(2) zinc-fingers (C2H2 ZFs) mediate a wide variety of protein–DNA and protein–protein interactions. DNA-binding C2H2 ZFs can be shuffled to yield artificial proteins with different DNA-binding specificities. Here we demonstrate that shuffling of C2H2 ZFs from transcription factor dimerizati...

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Detalles Bibliográficos
Autores principales: Giesecke, Astrid V, Fang, Rui, Joung, J Keith
Formato: Texto
Lenguaje:English
Publicado: 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681485/
https://www.ncbi.nlm.nih.gov/pubmed/16732192
http://dx.doi.org/10.1038/msb4100053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681485/
https://www.ncbi.nlm.nih.gov/pubmed/16732192
http://dx.doi.org/10.1038/msb4100053

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