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A comprehensive map of the toll-like receptor signaling network

Recognition of pathogen-associated molecular signatures is critically important in proper activation of the immune system. The toll-like receptor (TLR) signaling network is responsible for innate immune response. In mammalians, there are 11 TLRs that recognize a variety of ligands from pathogens to...

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Detalles Bibliográficos
Autores principales: Oda, Kanae, Kitano, Hiroaki
Formato: Texto
Lenguaje:English
Publicado: 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681489/
https://www.ncbi.nlm.nih.gov/pubmed/16738560
http://dx.doi.org/10.1038/msb4100057
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author Oda, Kanae
Kitano, Hiroaki
author_facet Oda, Kanae
Kitano, Hiroaki
author_sort Oda, Kanae
collection PubMed
description Recognition of pathogen-associated molecular signatures is critically important in proper activation of the immune system. The toll-like receptor (TLR) signaling network is responsible for innate immune response. In mammalians, there are 11 TLRs that recognize a variety of ligands from pathogens to trigger immunological responses. In this paper, we present a comprehensive map of TLRs and interleukin 1 receptor signaling networks based on papers published so far. The map illustrates the possible existence of a main network subsystem that has a bow-tie structure in which myeloid differentiation primary response gene 88 (MyD88) is a nonredundant core element, two collateral subsystems with small GTPase and phosphatidylinositol signaling, and MyD88-independent pathway. There is extensive crosstalk between the main bow-tie network and subsystems, as well as feedback and feedforward controls. One obvious feature of this network is the fragility against removal of the nonredundant core element, which is MyD88, and involvement of collateral subsystems for generating different reactions and gene expressions for different stimuli.
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spelling pubmed-16814892007-01-25 A comprehensive map of the toll-like receptor signaling network Oda, Kanae Kitano, Hiroaki Mol Syst Biol Review Article Recognition of pathogen-associated molecular signatures is critically important in proper activation of the immune system. The toll-like receptor (TLR) signaling network is responsible for innate immune response. In mammalians, there are 11 TLRs that recognize a variety of ligands from pathogens to trigger immunological responses. In this paper, we present a comprehensive map of TLRs and interleukin 1 receptor signaling networks based on papers published so far. The map illustrates the possible existence of a main network subsystem that has a bow-tie structure in which myeloid differentiation primary response gene 88 (MyD88) is a nonredundant core element, two collateral subsystems with small GTPase and phosphatidylinositol signaling, and MyD88-independent pathway. There is extensive crosstalk between the main bow-tie network and subsystems, as well as feedback and feedforward controls. One obvious feature of this network is the fragility against removal of the nonredundant core element, which is MyD88, and involvement of collateral subsystems for generating different reactions and gene expressions for different stimuli. 2006-04-18 /pmc/articles/PMC1681489/ /pubmed/16738560 http://dx.doi.org/10.1038/msb4100057 Text en Copyright © 2006, EMBO and Nature Publishing Group
spellingShingle Review Article
Oda, Kanae
Kitano, Hiroaki
A comprehensive map of the toll-like receptor signaling network
title A comprehensive map of the toll-like receptor signaling network
title_full A comprehensive map of the toll-like receptor signaling network
title_fullStr A comprehensive map of the toll-like receptor signaling network
title_full_unstemmed A comprehensive map of the toll-like receptor signaling network
title_short A comprehensive map of the toll-like receptor signaling network
title_sort comprehensive map of the toll-like receptor signaling network
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681489/
https://www.ncbi.nlm.nih.gov/pubmed/16738560
http://dx.doi.org/10.1038/msb4100057
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