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A comprehensive map of the toll-like receptor signaling network
Recognition of pathogen-associated molecular signatures is critically important in proper activation of the immune system. The toll-like receptor (TLR) signaling network is responsible for innate immune response. In mammalians, there are 11 TLRs that recognize a variety of ligands from pathogens to...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681489/ https://www.ncbi.nlm.nih.gov/pubmed/16738560 http://dx.doi.org/10.1038/msb4100057 |
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author | Oda, Kanae Kitano, Hiroaki |
author_facet | Oda, Kanae Kitano, Hiroaki |
author_sort | Oda, Kanae |
collection | PubMed |
description | Recognition of pathogen-associated molecular signatures is critically important in proper activation of the immune system. The toll-like receptor (TLR) signaling network is responsible for innate immune response. In mammalians, there are 11 TLRs that recognize a variety of ligands from pathogens to trigger immunological responses. In this paper, we present a comprehensive map of TLRs and interleukin 1 receptor signaling networks based on papers published so far. The map illustrates the possible existence of a main network subsystem that has a bow-tie structure in which myeloid differentiation primary response gene 88 (MyD88) is a nonredundant core element, two collateral subsystems with small GTPase and phosphatidylinositol signaling, and MyD88-independent pathway. There is extensive crosstalk between the main bow-tie network and subsystems, as well as feedback and feedforward controls. One obvious feature of this network is the fragility against removal of the nonredundant core element, which is MyD88, and involvement of collateral subsystems for generating different reactions and gene expressions for different stimuli. |
format | Text |
id | pubmed-1681489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
record_format | MEDLINE/PubMed |
spelling | pubmed-16814892007-01-25 A comprehensive map of the toll-like receptor signaling network Oda, Kanae Kitano, Hiroaki Mol Syst Biol Review Article Recognition of pathogen-associated molecular signatures is critically important in proper activation of the immune system. The toll-like receptor (TLR) signaling network is responsible for innate immune response. In mammalians, there are 11 TLRs that recognize a variety of ligands from pathogens to trigger immunological responses. In this paper, we present a comprehensive map of TLRs and interleukin 1 receptor signaling networks based on papers published so far. The map illustrates the possible existence of a main network subsystem that has a bow-tie structure in which myeloid differentiation primary response gene 88 (MyD88) is a nonredundant core element, two collateral subsystems with small GTPase and phosphatidylinositol signaling, and MyD88-independent pathway. There is extensive crosstalk between the main bow-tie network and subsystems, as well as feedback and feedforward controls. One obvious feature of this network is the fragility against removal of the nonredundant core element, which is MyD88, and involvement of collateral subsystems for generating different reactions and gene expressions for different stimuli. 2006-04-18 /pmc/articles/PMC1681489/ /pubmed/16738560 http://dx.doi.org/10.1038/msb4100057 Text en Copyright © 2006, EMBO and Nature Publishing Group |
spellingShingle | Review Article Oda, Kanae Kitano, Hiroaki A comprehensive map of the toll-like receptor signaling network |
title | A comprehensive map of the toll-like receptor signaling network |
title_full | A comprehensive map of the toll-like receptor signaling network |
title_fullStr | A comprehensive map of the toll-like receptor signaling network |
title_full_unstemmed | A comprehensive map of the toll-like receptor signaling network |
title_short | A comprehensive map of the toll-like receptor signaling network |
title_sort | comprehensive map of the toll-like receptor signaling network |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681489/ https://www.ncbi.nlm.nih.gov/pubmed/16738560 http://dx.doi.org/10.1038/msb4100057 |
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