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Prognostic value of angiogenesis evaluated with high-frequency and colour Doppler sonography for preoperative assessment of primary cutaneous melanomas: correlation with recurrence after a 5 year follow-up period
Objective: To study the value of high-frequency sonography (HFS) and colour Doppler sonography (CDS) in evaluating the 5 year metastatic potential of primary cutaneous melanomas (CM). Materials and methods: 111 CM were studied before surgical resection and 107 were depicted on HFS. The maximal HFS t...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
e-MED
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693780/ https://www.ncbi.nlm.nih.gov/pubmed/16644502 http://dx.doi.org/10.1102/1470-7330.2006.0009 |
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author | Lassau, Nathalie Lamuraglia, Michele Koscielny, Serge Spatz, Alain Roche, Alain Leclere, Jerome Avril, Marie-Françoise |
author_facet | Lassau, Nathalie Lamuraglia, Michele Koscielny, Serge Spatz, Alain Roche, Alain Leclere, Jerome Avril, Marie-Françoise |
author_sort | Lassau, Nathalie |
collection | PubMed |
description | Objective: To study the value of high-frequency sonography (HFS) and colour Doppler sonography (CDS) in evaluating the 5 year metastatic potential of primary cutaneous melanomas (CM). Materials and methods: 111 CM were studied before surgical resection and 107 were depicted on HFS. The maximal HFS thickness was measured and compared with the Breslow thickness. A CDS study was performed in each tumour. Results: HFS thickness ranged from 0.26 to 8.0 mm and Breslow thickness from 0.15 to 8.0 mm. HFS and Breslow thickness correlated strongly (r>0.93). Intratumour vessels were depicted in 43 of the 107 CM, of which 40 were thicker than 2 mm. The median follow-up was 61 months and 27 patients developed relapses. In the univariate analyses, neovascularization visualized with CDS, sonographic thickness and the Breslow thickness were significantly linked to relapses (p<0.0001), as were lymph node status and ulceration (p=0.007 and 0.004). Conclusion: Vascularization was observed mainly in thick primary melanoma. A median follow-up of 5 years showed the prognostic value of angiogenesis evaluated by CDS. |
format | Text |
id | pubmed-1693780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | e-MED |
record_format | MEDLINE/PubMed |
spelling | pubmed-16937802007-04-25 Prognostic value of angiogenesis evaluated with high-frequency and colour Doppler sonography for preoperative assessment of primary cutaneous melanomas: correlation with recurrence after a 5 year follow-up period Lassau, Nathalie Lamuraglia, Michele Koscielny, Serge Spatz, Alain Roche, Alain Leclere, Jerome Avril, Marie-Françoise Cancer Imaging Article Objective: To study the value of high-frequency sonography (HFS) and colour Doppler sonography (CDS) in evaluating the 5 year metastatic potential of primary cutaneous melanomas (CM). Materials and methods: 111 CM were studied before surgical resection and 107 were depicted on HFS. The maximal HFS thickness was measured and compared with the Breslow thickness. A CDS study was performed in each tumour. Results: HFS thickness ranged from 0.26 to 8.0 mm and Breslow thickness from 0.15 to 8.0 mm. HFS and Breslow thickness correlated strongly (r>0.93). Intratumour vessels were depicted in 43 of the 107 CM, of which 40 were thicker than 2 mm. The median follow-up was 61 months and 27 patients developed relapses. In the univariate analyses, neovascularization visualized with CDS, sonographic thickness and the Breslow thickness were significantly linked to relapses (p<0.0001), as were lymph node status and ulceration (p=0.007 and 0.004). Conclusion: Vascularization was observed mainly in thick primary melanoma. A median follow-up of 5 years showed the prognostic value of angiogenesis evaluated by CDS. e-MED 2006-04-25 /pmc/articles/PMC1693780/ /pubmed/16644502 http://dx.doi.org/10.1102/1470-7330.2006.0009 Text en Copyright © 2006 International Cancer Imaging Society |
spellingShingle | Article Lassau, Nathalie Lamuraglia, Michele Koscielny, Serge Spatz, Alain Roche, Alain Leclere, Jerome Avril, Marie-Françoise Prognostic value of angiogenesis evaluated with high-frequency and colour Doppler sonography for preoperative assessment of primary cutaneous melanomas: correlation with recurrence after a 5 year follow-up period |
title | Prognostic value of angiogenesis evaluated with high-frequency and colour Doppler sonography for preoperative assessment of primary cutaneous melanomas: correlation with recurrence after a 5 year follow-up period |
title_full | Prognostic value of angiogenesis evaluated with high-frequency and colour Doppler sonography for preoperative assessment of primary cutaneous melanomas: correlation with recurrence after a 5 year follow-up period |
title_fullStr | Prognostic value of angiogenesis evaluated with high-frequency and colour Doppler sonography for preoperative assessment of primary cutaneous melanomas: correlation with recurrence after a 5 year follow-up period |
title_full_unstemmed | Prognostic value of angiogenesis evaluated with high-frequency and colour Doppler sonography for preoperative assessment of primary cutaneous melanomas: correlation with recurrence after a 5 year follow-up period |
title_short | Prognostic value of angiogenesis evaluated with high-frequency and colour Doppler sonography for preoperative assessment of primary cutaneous melanomas: correlation with recurrence after a 5 year follow-up period |
title_sort | prognostic value of angiogenesis evaluated with high-frequency and colour doppler sonography for preoperative assessment of primary cutaneous melanomas: correlation with recurrence after a 5 year follow-up period |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693780/ https://www.ncbi.nlm.nih.gov/pubmed/16644502 http://dx.doi.org/10.1102/1470-7330.2006.0009 |
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