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Position-dependent effects of locked nucleic acid (LNA) on DNA sequencing and PCR primers
Genomes are becoming heavily annotated with important features. Analysis of these features often employs oligonucleotides that hybridize at defined locations. When the defined location lies in a poor sequence context, traditional design strategies may fail. Locked Nucleic Acid (LNA) can enhance olig...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1694044/ https://www.ncbi.nlm.nih.gov/pubmed/17071964 http://dx.doi.org/10.1093/nar/gkl756 |