DNA Microarrays in Herbal Drug Research

Natural products are gaining increased applications in drug discovery and development. Being chemically diverse they are able to modulate several targets simultaneously in a complex system. Analysis of gene expression becomes necessary for better understanding of molecular mechanisms. Conventional s...

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Detalles Bibliográficos
Autores principales: Chavan, Preeti, Joshi, Kalpana, Patwardhan, Bhushan
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1697755/
https://www.ncbi.nlm.nih.gov/pubmed/17173108
http://dx.doi.org/10.1093/ecam/nel075
Descripción
Sumario:Natural products are gaining increased applications in drug discovery and development. Being chemically diverse they are able to modulate several targets simultaneously in a complex system. Analysis of gene expression becomes necessary for better understanding of molecular mechanisms. Conventional strategies for expression profiling are optimized for single gene analysis. DNA microarrays serve as suitable high throughput tool for simultaneous analysis of multiple genes. Major practical applicability of DNA microarrays remains in DNA mutation and polymorphism analysis. This review highlights applications of DNA microarrays in pharmacodynamics, pharmacogenomics, toxicogenomics and quality control of herbal drugs and extracts.

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