Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome

Cockayne syndrome (CS) is a photosensitive, DNA repair disorder associated with progeria that is caused by a defect in the transcription-coupled repair subpathway of nucleotide excision repair (NER). Here, complete inactivation of NER in Csb(m/m)/Xpa(−/−) mutants causes a phenotype that reliably mim...

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Detalles Bibliográficos
Autores principales: van der Pluijm, Ingrid, Garinis, George A, Brandt, Renata M. C, Gorgels, Theo G. M. F, Wijnhoven, Susan W, Diderich, Karin E. M, de Wit, Jan, Mitchell, James R, van Oostrom, Conny, Beems, Rudolf, Niedernhofer, Laura J, Velasco, Susana, Friedberg, Errol C, Tanaka, Kiyoji, van Steeg, Harry, Hoeijmakers, Jan H. J, van der Horst, Gijsbertus T. J
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698505/
https://www.ncbi.nlm.nih.gov/pubmed/17326724
http://dx.doi.org/10.1371/journal.pbio.0050002

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