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Activation of RegB endoribonuclease by S1 ribosomal protein requires an 11 nt conserved sequence

The T4 RegB endoribonuclease cleaves specifically in the middle of the -GGAG- sequence, leading to inactivation and degradation of early phage mRNAs. In vitro, RegB activity is very weak but can be enhanced 10- to 100-fold by the Escherichia coli ribosomal protein S1. Not all RNAs carrying the GGAG...

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Detalles Bibliográficos
Autores principales:	Durand, Sylvain, Richard, Graziella, Bisaglia, Marco, Laalami, Soumaya, Bontems, François, Uzan, Marc
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702504/ https://www.ncbi.nlm.nih.gov/pubmed/17130171 http://dx.doi.org/10.1093/nar/gkl911

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