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Trend towards varying combinatorial centromere association in morphologically identical clusters in Purkinje neurons

Neurons with similar morphology and neurotransmitter content located at a specific brain region may be part of the same or functionally separate networks. To address the question whether morphologically similar neurons have similar structural architecture at the chromosomal level, we studied Purkinj...

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Autores principales: Vadakkan, Kunjumon I, Li, Baoxiang, De Boni, Umberto
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702546/
https://www.ncbi.nlm.nih.gov/pubmed/17156432
http://dx.doi.org/10.1186/1475-9268-5-1
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author Vadakkan, Kunjumon I
Li, Baoxiang
De Boni, Umberto
author_facet Vadakkan, Kunjumon I
Li, Baoxiang
De Boni, Umberto
author_sort Vadakkan, Kunjumon I
collection PubMed
description Neurons with similar morphology and neurotransmitter content located at a specific brain region may be part of the same or functionally separate networks. To address the question whether morphologically similar neurons have similar structural architecture at the chromosomal level, we studied Purkinje neurons in the cerebellum. Previous studies have shown that in Purkinje neurons centromeres of several chromosomes form clusters and that the number and size of these clusters remain stable in the adult brain. We examined whether the same set of centromeres form clusters in all the Purkinje neurons. Fluorescent in situ hybridization (FISH) with chromosome-specific para-centromeric probes provided an indirect evidence for a trend towards varying contributions from different chromosomes forming the centromeric clusters in adjacent Purkinje neurons. The results of the study indicate that the individual Purkinje neurons are likely unique in inter-chromosomal spatial associations.
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spelling pubmed-17025462006-12-16 Trend towards varying combinatorial centromere association in morphologically identical clusters in Purkinje neurons Vadakkan, Kunjumon I Li, Baoxiang De Boni, Umberto Cell Chromosome Research Neurons with similar morphology and neurotransmitter content located at a specific brain region may be part of the same or functionally separate networks. To address the question whether morphologically similar neurons have similar structural architecture at the chromosomal level, we studied Purkinje neurons in the cerebellum. Previous studies have shown that in Purkinje neurons centromeres of several chromosomes form clusters and that the number and size of these clusters remain stable in the adult brain. We examined whether the same set of centromeres form clusters in all the Purkinje neurons. Fluorescent in situ hybridization (FISH) with chromosome-specific para-centromeric probes provided an indirect evidence for a trend towards varying contributions from different chromosomes forming the centromeric clusters in adjacent Purkinje neurons. The results of the study indicate that the individual Purkinje neurons are likely unique in inter-chromosomal spatial associations. BioMed Central 2006-12-07 /pmc/articles/PMC1702546/ /pubmed/17156432 http://dx.doi.org/10.1186/1475-9268-5-1 Text en Copyright © 2006 Vadakkan et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Vadakkan, Kunjumon I
Li, Baoxiang
De Boni, Umberto
Trend towards varying combinatorial centromere association in morphologically identical clusters in Purkinje neurons
title Trend towards varying combinatorial centromere association in morphologically identical clusters in Purkinje neurons
title_full Trend towards varying combinatorial centromere association in morphologically identical clusters in Purkinje neurons
title_fullStr Trend towards varying combinatorial centromere association in morphologically identical clusters in Purkinje neurons
title_full_unstemmed Trend towards varying combinatorial centromere association in morphologically identical clusters in Purkinje neurons
title_short Trend towards varying combinatorial centromere association in morphologically identical clusters in Purkinje neurons
title_sort trend towards varying combinatorial centromere association in morphologically identical clusters in purkinje neurons
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702546/
https://www.ncbi.nlm.nih.gov/pubmed/17156432
http://dx.doi.org/10.1186/1475-9268-5-1
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