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Anti-vascular agent Combretastatin A-4-P modulates Hypoxia Inducible Factor-1 and gene expression

BACKGROUND: A functional vascular network is essential for the survival, growth and spread of solid tumours, making blood vessels a key target for therapeutic strategies. Combretastatin A-4 phosphate (CA-4-P) is a tubulin-depolymerising agent in Phase II clinical trials as a vascular disrupting agen...

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Detalles Bibliográficos
Autores principales:	Dachs, Gabi U, Steele, Andrew J, Coralli, Claudia, Kanthou, Chryso, Brooks, Andrew C, Gunningham, Sarah P, Currie, Margaret J, Watson, Ally I, Robinson, Bridget A, Tozer, Gillian M
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1702548/ https://www.ncbi.nlm.nih.gov/pubmed/17156434 http://dx.doi.org/10.1186/1471-2407-6-280

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