A Genome-Wide Screen for Promoter Methylation in Lung Cancer Identifies Novel Methylation Markers for Multiple Malignancies

BACKGROUND: Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The “rules” governing which genes are methylated during the pathogenesis of individual cancers, how specific methylation profiles are initially establishe...

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Detalles Bibliográficos
Autores principales: Shames, David S, Girard, Luc, Gao, Boning, Sato, Mitsuo, Lewis, Cheryl M, Shivapurkar, Narayan, Jiang, Aixiang, Perou, Charles M, Kim, Young H, Pollack, Jonathan R, Fong, Kwun M, Lam, Chi-Leung, Wong, Maria, Shyr, Yu, Nanda, Rita, Olopade, Olufunmilayo I, Gerald, William, Euhus, David M, Shay, Jerry W, Gazdar, Adi F, Minna, John D
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1716188/
https://www.ncbi.nlm.nih.gov/pubmed/17194187
http://dx.doi.org/10.1371/journal.pmed.0030486

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