Cargando…
A Plant-Derived Morphinan as a Novel Lead Compound Active against Malaria Liver Stages
BACKGROUND: The global spread of multidrug–resistant malaria parasites has led to an urgent need for new chemotherapeutic agents. Drug discovery is primarily directed to the asexual blood stages, and few drugs that are effective against the obligatory liver stages, from which the pathogenic blood in...
Autores principales: | Carraz, Maëlle, Jossang, Akino, Franetich, Jean-François, Siau, Anthony, Ciceron, Liliane, Hannoun, Laurent, Sauerwein, Robert, Frappier, François, Rasoanaivo, Philippe, Snounou, Georges, Mazier, Dominique |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2006
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1716192/ https://www.ncbi.nlm.nih.gov/pubmed/17194195 http://dx.doi.org/10.1371/journal.pmed.0030513 |
Ejemplares similares
-
Potent Antiplasmodial Derivatives of Dextromethorphan Reveal the Ent-Morphinan Pharmacophore of Tazopsine-Type Alkaloids
por: Keita, Antoinette, et al.
Publicado: (2022) -
Inhibitory Effect of TNF-α on Malaria Pre-Erythrocytic Stage Development: Influence of Host Hepatocyte/Parasite Combinations
por: Depinay, Nadya, et al.
Publicado: (2011) -
Skin-draining lymph node priming is sufficient to induce sterile immunity against pre-erythrocytic malaria
por: Obeid, Michel, et al.
Publicado: (2013) -
Temperature Shift and Host Cell Contact Up-Regulate Sporozoite Expression of Plasmodium falciparum Genes Involved in Hepatocyte Infection
por: Siau, Anthony, et al.
Publicado: (2008) -
A Role for Immune Responses against Non-CS Components in the Cross-Species Protection Induced by Immunization with Irradiated Malaria Sporozoites
por: Mauduit, Marjorie, et al.
Publicado: (2009)