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Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors
The multidrug exporter AcrB is the inner membrane component of the AcrAB-TolC drug efflux system in Escherichia coli and is responsible for the resistance of this organism to a wide range of drugs. Here we describe the crystal structure of the trimeric AcrB in complex with a designed ankyrin-repeat...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1717020/ https://www.ncbi.nlm.nih.gov/pubmed/17194213 http://dx.doi.org/10.1371/journal.pbio.0050007 |