Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding

Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterized by a loss of α motoneurons in the spinal cord. SMA is caused by low levels of the ubiquitously expressed survival motor neuron (Smn) protein. As it is unclear how low levels of Smn specifically affect motoneurons, we have...

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Detalles Bibliográficos
Autores principales: McWhorter, Michelle L., Monani, Umrao R., Burghes, Arthur H.M., Beattie, Christine E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761110/
https://www.ncbi.nlm.nih.gov/pubmed/12952942
http://dx.doi.org/10.1083/jcb.200303168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761110/
https://www.ncbi.nlm.nih.gov/pubmed/12952942
http://dx.doi.org/10.1083/jcb.200303168

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