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A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee

The honeybee genome has substantially fewer protein coding genes (≈ 11 000 genes) than Drosophila melanogaster (≈ 13 500) and Anopheles gambiae (≈ 14 000). Some of the most marked differences occur in three superfamilies encoding xenobiotic detoxifying enzymes. Specifically there are only about half...

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Autores principales: Claudianos, C, Ranson, H, Johnson, R M, Biswas, S, Schuler, M A, Berenbaum, M R, Feyereisen, R, Oakeshott, J G
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761136/
https://www.ncbi.nlm.nih.gov/pubmed/17069637
http://dx.doi.org/10.1111/j.1365-2583.2006.00672.x
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author Claudianos, C
Ranson, H
Johnson, R M
Biswas, S
Schuler, M A
Berenbaum, M R
Feyereisen, R
Oakeshott, J G
author_facet Claudianos, C
Ranson, H
Johnson, R M
Biswas, S
Schuler, M A
Berenbaum, M R
Feyereisen, R
Oakeshott, J G
author_sort Claudianos, C
collection PubMed
description The honeybee genome has substantially fewer protein coding genes (≈ 11 000 genes) than Drosophila melanogaster (≈ 13 500) and Anopheles gambiae (≈ 14 000). Some of the most marked differences occur in three superfamilies encoding xenobiotic detoxifying enzymes. Specifically there are only about half as many glutathione-S-transferases (GSTs), cytochrome P450 monooxygenases (P450s) and carboxyl/cholinesterases (CCEs) in the honeybee. This includes 10-fold or greater shortfalls in the numbers of Delta and Epsilon GSTs and CYP4 P450s, members of which clades have been recurrently associated with insecticide resistance in other species. These shortfalls may contribute to the sensitivity of the honeybee to insecticides. On the other hand there are some recent radiations in CYP6, CYP9 and certain CCE clades in A. mellifera that could be associated with the evolution of the hormonal and chemosensory processes underpinning its highly organized eusociality.
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spelling pubmed-17611362007-01-18 A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee Claudianos, C Ranson, H Johnson, R M Biswas, S Schuler, M A Berenbaum, M R Feyereisen, R Oakeshott, J G Insect Mol Biol Special Issue: The Honey Bee Genome The honeybee genome has substantially fewer protein coding genes (≈ 11 000 genes) than Drosophila melanogaster (≈ 13 500) and Anopheles gambiae (≈ 14 000). Some of the most marked differences occur in three superfamilies encoding xenobiotic detoxifying enzymes. Specifically there are only about half as many glutathione-S-transferases (GSTs), cytochrome P450 monooxygenases (P450s) and carboxyl/cholinesterases (CCEs) in the honeybee. This includes 10-fold or greater shortfalls in the numbers of Delta and Epsilon GSTs and CYP4 P450s, members of which clades have been recurrently associated with insecticide resistance in other species. These shortfalls may contribute to the sensitivity of the honeybee to insecticides. On the other hand there are some recent radiations in CYP6, CYP9 and certain CCE clades in A. mellifera that could be associated with the evolution of the hormonal and chemosensory processes underpinning its highly organized eusociality. Blackwell Publishing Ltd 2006-10 /pmc/articles/PMC1761136/ /pubmed/17069637 http://dx.doi.org/10.1111/j.1365-2583.2006.00672.x Text en © 2006 The Authors Journal compilation © 2006 The Royal Entomological Society https://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Special Issue: The Honey Bee Genome
Claudianos, C
Ranson, H
Johnson, R M
Biswas, S
Schuler, M A
Berenbaum, M R
Feyereisen, R
Oakeshott, J G
A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee
title A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee
title_full A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee
title_fullStr A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee
title_full_unstemmed A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee
title_short A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee
title_sort deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee
topic Special Issue: The Honey Bee Genome
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761136/
https://www.ncbi.nlm.nih.gov/pubmed/17069637
http://dx.doi.org/10.1111/j.1365-2583.2006.00672.x
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