Triose Phosphate Isomerase Deficiency Is Caused by Altered Dimerization–Not Catalytic Inactivity–of the Mutant Enzymes

Triosephosphate isomerase (TPI) deficiency is an autosomal recessive disorder caused by various mutations in the gene encoding the key glycolytic enzyme TPI. A drastic decrease in TPI activity and an increased level of its substrate, dihydroxyacetone phosphate, have been measured in unpurified cell...

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Detalles Bibliográficos
Autores principales: Ralser, Markus, Heeren, Gino, Breitenbach, Michael, Lehrach, Hans, Krobitsch, Sylvia
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762313/
https://www.ncbi.nlm.nih.gov/pubmed/17183658
http://dx.doi.org/10.1371/journal.pone.0000030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762313/
https://www.ncbi.nlm.nih.gov/pubmed/17183658
http://dx.doi.org/10.1371/journal.pone.0000030

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