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Fine Tuning of Globin Gene Expression by DNA Methylation

Expression patterns in the globin gene cluster are subject to developmental regulation in vivo. While the γ(A) and γ(G) genes are expressed in fetal liver, both are silenced in adult erythrocytes. In order to decipher the role of DNA methylation in this process, we generated a YAC transgenic mouse s...

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Detalles Bibliográficos
Autores principales:	Goren, Alon, Simchen, Giora, Fibach, Eitan, Szabo, Piroska E., Tanimoto, Keiji, Chakalova, Lyubomira, Pfeifer, Gerd P., Fraser, Peter J., Engel, James D., Cedar, Howard
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762317/ https://www.ncbi.nlm.nih.gov/pubmed/17183675 http://dx.doi.org/10.1371/journal.pone.0000046

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