Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine

Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we...

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Detalles Bibliográficos
Autores principales: Sonoyama, Wataru, Liu, Yi, Fang, Dianji, Yamaza, Takayoshi, Seo, Byoung-Moo, Zhang, Chunmei, Liu, He, Gronthos, Stan, Wang, Cun-Yu, Shi, Songtao, Wang, Songlin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762318/
https://www.ncbi.nlm.nih.gov/pubmed/17183711
http://dx.doi.org/10.1371/journal.pone.0000079
Descripción
Sumario:Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance.

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