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Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves

Recent analyses have questioned the usefulness of heterozygosity estimates as measures of the inbreeding coefficient (f), a finding that may have dramatic consequences for the management of endangered populations. We confirm that f and heterozygosity is poorly correlated in a wild and highly inbred...

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Autores principales: Bensch, Staffan, Andrén, Henrik, Hansson, Bengt, Pedersen, Hans Chr., Sand, Håkan, Sejberg, Douglas, Wabakken, Petter, Åkesson, Mikael, Liberg, Olof
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762340/
https://www.ncbi.nlm.nih.gov/pubmed/17183704
http://dx.doi.org/10.1371/journal.pone.0000072
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author Bensch, Staffan
Andrén, Henrik
Hansson, Bengt
Pedersen, Hans Chr.
Sand, Håkan
Sejberg, Douglas
Wabakken, Petter
Åkesson, Mikael
Liberg, Olof
author_facet Bensch, Staffan
Andrén, Henrik
Hansson, Bengt
Pedersen, Hans Chr.
Sand, Håkan
Sejberg, Douglas
Wabakken, Petter
Åkesson, Mikael
Liberg, Olof
author_sort Bensch, Staffan
collection PubMed
description Recent analyses have questioned the usefulness of heterozygosity estimates as measures of the inbreeding coefficient (f), a finding that may have dramatic consequences for the management of endangered populations. We confirm that f and heterozygosity is poorly correlated in a wild and highly inbred wolf population. Yet, our data show that for each level of f, it was the most heterozygous wolves that established themselves as breeders, a selection process that seems to have decelerated the loss of heterozygosity in the population despite a steady increase of f. The markers contributing to the positive relationship between heterozygosity and breeding success were found to be located on different chromosomes, but there was a substantial amount of linkage disequilibrium in the population, indicating that the markers are reflecting heterozygosity over relatively wide genomic regions. Following our results we recommend that management programs of endangered populations include estimates of both f and heterozygosity, as they may contribute with complementary information about population viability.
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spelling pubmed-17623402007-01-04 Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves Bensch, Staffan Andrén, Henrik Hansson, Bengt Pedersen, Hans Chr. Sand, Håkan Sejberg, Douglas Wabakken, Petter Åkesson, Mikael Liberg, Olof PLoS One Research Article Recent analyses have questioned the usefulness of heterozygosity estimates as measures of the inbreeding coefficient (f), a finding that may have dramatic consequences for the management of endangered populations. We confirm that f and heterozygosity is poorly correlated in a wild and highly inbred wolf population. Yet, our data show that for each level of f, it was the most heterozygous wolves that established themselves as breeders, a selection process that seems to have decelerated the loss of heterozygosity in the population despite a steady increase of f. The markers contributing to the positive relationship between heterozygosity and breeding success were found to be located on different chromosomes, but there was a substantial amount of linkage disequilibrium in the population, indicating that the markers are reflecting heterozygosity over relatively wide genomic regions. Following our results we recommend that management programs of endangered populations include estimates of both f and heterozygosity, as they may contribute with complementary information about population viability. Public Library of Science 2006-12-20 /pmc/articles/PMC1762340/ /pubmed/17183704 http://dx.doi.org/10.1371/journal.pone.0000072 Text en Bensch et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Bensch, Staffan
Andrén, Henrik
Hansson, Bengt
Pedersen, Hans Chr.
Sand, Håkan
Sejberg, Douglas
Wabakken, Petter
Åkesson, Mikael
Liberg, Olof
Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves
title Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves
title_full Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves
title_fullStr Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves
title_full_unstemmed Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves
title_short Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves
title_sort selection for heterozygosity gives hope to a wild population of inbred wolves
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762340/
https://www.ncbi.nlm.nih.gov/pubmed/17183704
http://dx.doi.org/10.1371/journal.pone.0000072
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