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Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves
Recent analyses have questioned the usefulness of heterozygosity estimates as measures of the inbreeding coefficient (f), a finding that may have dramatic consequences for the management of endangered populations. We confirm that f and heterozygosity is poorly correlated in a wild and highly inbred...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762340/ https://www.ncbi.nlm.nih.gov/pubmed/17183704 http://dx.doi.org/10.1371/journal.pone.0000072 |
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author | Bensch, Staffan Andrén, Henrik Hansson, Bengt Pedersen, Hans Chr. Sand, Håkan Sejberg, Douglas Wabakken, Petter Åkesson, Mikael Liberg, Olof |
author_facet | Bensch, Staffan Andrén, Henrik Hansson, Bengt Pedersen, Hans Chr. Sand, Håkan Sejberg, Douglas Wabakken, Petter Åkesson, Mikael Liberg, Olof |
author_sort | Bensch, Staffan |
collection | PubMed |
description | Recent analyses have questioned the usefulness of heterozygosity estimates as measures of the inbreeding coefficient (f), a finding that may have dramatic consequences for the management of endangered populations. We confirm that f and heterozygosity is poorly correlated in a wild and highly inbred wolf population. Yet, our data show that for each level of f, it was the most heterozygous wolves that established themselves as breeders, a selection process that seems to have decelerated the loss of heterozygosity in the population despite a steady increase of f. The markers contributing to the positive relationship between heterozygosity and breeding success were found to be located on different chromosomes, but there was a substantial amount of linkage disequilibrium in the population, indicating that the markers are reflecting heterozygosity over relatively wide genomic regions. Following our results we recommend that management programs of endangered populations include estimates of both f and heterozygosity, as they may contribute with complementary information about population viability. |
format | Text |
id | pubmed-1762340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-17623402007-01-04 Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves Bensch, Staffan Andrén, Henrik Hansson, Bengt Pedersen, Hans Chr. Sand, Håkan Sejberg, Douglas Wabakken, Petter Åkesson, Mikael Liberg, Olof PLoS One Research Article Recent analyses have questioned the usefulness of heterozygosity estimates as measures of the inbreeding coefficient (f), a finding that may have dramatic consequences for the management of endangered populations. We confirm that f and heterozygosity is poorly correlated in a wild and highly inbred wolf population. Yet, our data show that for each level of f, it was the most heterozygous wolves that established themselves as breeders, a selection process that seems to have decelerated the loss of heterozygosity in the population despite a steady increase of f. The markers contributing to the positive relationship between heterozygosity and breeding success were found to be located on different chromosomes, but there was a substantial amount of linkage disequilibrium in the population, indicating that the markers are reflecting heterozygosity over relatively wide genomic regions. Following our results we recommend that management programs of endangered populations include estimates of both f and heterozygosity, as they may contribute with complementary information about population viability. Public Library of Science 2006-12-20 /pmc/articles/PMC1762340/ /pubmed/17183704 http://dx.doi.org/10.1371/journal.pone.0000072 Text en Bensch et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Bensch, Staffan Andrén, Henrik Hansson, Bengt Pedersen, Hans Chr. Sand, Håkan Sejberg, Douglas Wabakken, Petter Åkesson, Mikael Liberg, Olof Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves |
title | Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves |
title_full | Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves |
title_fullStr | Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves |
title_full_unstemmed | Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves |
title_short | Selection for Heterozygosity Gives Hope to a Wild Population of Inbred Wolves |
title_sort | selection for heterozygosity gives hope to a wild population of inbred wolves |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762340/ https://www.ncbi.nlm.nih.gov/pubmed/17183704 http://dx.doi.org/10.1371/journal.pone.0000072 |
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