A Systems Biology Strategy Reveals Biological Pathways and Plasma Biomarker Candidates for Potentially Toxic Statin-Induced Changes in Muscle

BACKGROUND: Aggressive lipid lowering with high doses of statins increases the risk of statin-induced myopathy. However, the cellular mechanisms leading to muscle damage are not known and sensitive biomarkers are needed to identify patients at risk of developing statin-induced serious side effects....

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Detalles Bibliográficos
Autores principales: Laaksonen, Reijo, Katajamaa, Mikko, Päivä, Hannu, Sysi-Aho, Marko, Saarinen, Lilli, Junni, Päivi, Lütjohann, Dieter, Smet, Joél, Van Coster, Rudy, Seppänen-Laakso, Tuulikki, Lehtimäki, Terho, Soini, Juhani, Orešič, Matej
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762369/
https://www.ncbi.nlm.nih.gov/pubmed/17183729
http://dx.doi.org/10.1371/journal.pone.0000097

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