HIV-1 Tat interaction with Dicer: requirement for RNA

Dicer is an RNase III which processes two classes of cellular small RNAs: the microRNAs (miRNA) and short interfering RNAs (siRNA). Previously, we observed that over-expressed HIV-1 Tat protein can suppress the processing of small RNAs inside cells. Here, we have investigated the requirements for Ta...

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Detalles Bibliográficos
Autores principales: Bennasser, Yamina, Jeang, Kuan-Teh
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764028/
https://www.ncbi.nlm.nih.gov/pubmed/17181864
http://dx.doi.org/10.1186/1742-4690-3-95
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author Bennasser, Yamina
Jeang, Kuan-Teh
author_facet Bennasser, Yamina
Jeang, Kuan-Teh
author_sort Bennasser, Yamina
collection PubMed
description Dicer is an RNase III which processes two classes of cellular small RNAs: the microRNAs (miRNA) and short interfering RNAs (siRNA). Previously, we observed that over-expressed HIV-1 Tat protein can suppress the processing of small RNAs inside cells. Here, we have investigated the requirements for Tat interaction with Dicer. We report that Tat-Dicer interaction depends on RNA, requires the helicase domain of Dicer, and is independent of Tat's transactivation domain.
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spelling pubmed-17640282007-01-05 HIV-1 Tat interaction with Dicer: requirement for RNA Bennasser, Yamina Jeang, Kuan-Teh Retrovirology Short Report Dicer is an RNase III which processes two classes of cellular small RNAs: the microRNAs (miRNA) and short interfering RNAs (siRNA). Previously, we observed that over-expressed HIV-1 Tat protein can suppress the processing of small RNAs inside cells. Here, we have investigated the requirements for Tat interaction with Dicer. We report that Tat-Dicer interaction depends on RNA, requires the helicase domain of Dicer, and is independent of Tat's transactivation domain. BioMed Central 2006-12-20 /pmc/articles/PMC1764028/ /pubmed/17181864 http://dx.doi.org/10.1186/1742-4690-3-95 Text en Copyright © 2006 Bennasser and Jeang; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Bennasser, Yamina
Jeang, Kuan-Teh
HIV-1 Tat interaction with Dicer: requirement for RNA
title HIV-1 Tat interaction with Dicer: requirement for RNA
title_full HIV-1 Tat interaction with Dicer: requirement for RNA
title_fullStr HIV-1 Tat interaction with Dicer: requirement for RNA
title_full_unstemmed HIV-1 Tat interaction with Dicer: requirement for RNA
title_short HIV-1 Tat interaction with Dicer: requirement for RNA
title_sort hiv-1 tat interaction with dicer: requirement for rna
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764028/
https://www.ncbi.nlm.nih.gov/pubmed/17181864
http://dx.doi.org/10.1186/1742-4690-3-95
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AT jeangkuanteh hiv1tatinteractionwithdicerrequirementforrna

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