Randomized Dose-Ranging Controlled Trial of AQ-13, a Candidate Antimalarial, and Chloroquine in Healthy Volunteers

OBJECTIVES: To determine: (1) the pharmacokinetics and safety of an investigational aminoquinoline active against multidrug–resistant malaria parasites (AQ-13), including its effects on the QT interval, and (2) whether it has pharmacokinetic and safety profiles similar to chloroquine (CQ) in humans....

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Detalles Bibliográficos
Autores principales: Mzayek, Fawaz, Deng, Haiyan, Mather, Frances J, Wasilevich, Elizabeth C, Liu, Huayin, Hadi, Christiane M, Chansolme, David H, Murphy, Holly A, Melek, Bekir H, Tenaglia, Alan N, Mushatt, David M, Dreisbach, Albert W, Lertora, Juan J. L, Krogstad, Donald J
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764434/
https://www.ncbi.nlm.nih.gov/pubmed/17213921
http://dx.doi.org/10.1371/journal.pctr.0020006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764434/
https://www.ncbi.nlm.nih.gov/pubmed/17213921
http://dx.doi.org/10.1371/journal.pctr.0020006

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