Cargando…
Randomized Dose-Ranging Controlled Trial of AQ-13, a Candidate Antimalarial, and Chloroquine in Healthy Volunteers
OBJECTIVES: To determine: (1) the pharmacokinetics and safety of an investigational aminoquinoline active against multidrug–resistant malaria parasites (AQ-13), including its effects on the QT interval, and (2) whether it has pharmacokinetic and safety profiles similar to chloroquine (CQ) in humans....
Autores principales: | Mzayek, Fawaz, Deng, Haiyan, Mather, Frances J, Wasilevich, Elizabeth C, Liu, Huayin, Hadi, Christiane M, Chansolme, David H, Murphy, Holly A, Melek, Bekir H, Tenaglia, Alan N, Mushatt, David M, Dreisbach, Albert W, Lertora, Juan J. L, Krogstad, Donald J |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764434/ https://www.ncbi.nlm.nih.gov/pubmed/17213921 http://dx.doi.org/10.1371/journal.pctr.0020006 |
Ejemplares similares
-
AQ-13, an investigational antimalarial, versus artemether plus lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria: a randomised, phase 2, non-inferiority clinical trial
por: Koita, Ousmane A, et al.
Publicado: (2017) -
Progress in the development of Reversed Chloroquine molecules as antimalarial therapy
por: Burgess, Steven J, et al.
Publicado: (2010) -
Dual-functioning antimalarials that inhibit the chloroquine-resistance transporter
por: Egan, Timothy J, et al.
Publicado: (2013) -
Cross-resistance of the chloroquine-derivative AQ-13 with amodiaquine in Cambodian Plasmodium falciparum isolates
por: Nardella, Flore, et al.
Publicado: (2021) -
Antimalarials (chloroquine and hydroxychloroquine) in the COVID-19 pandemic()
por: Jáuregui, Edwin
Publicado: (2021)