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Prevention and treatment of renal osteodystrophy in children on chronic renal failure: European guidelines
Childhood renal osteodystrophy (ROD) is the consequence of disturbances of the calcium-regulating hormones vitamin D and parathyroid hormone (PTH) as well as of the somatotroph hormone axis associated with local modulation of bone and growth cartilage function. The resulting growth retardation and t...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766475/ https://www.ncbi.nlm.nih.gov/pubmed/16247644 http://dx.doi.org/10.1007/s00467-005-2082-7 |
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author | Klaus, G. Watson, A. Edefonti, A. Fischbach, M. Rönnholm, K. Schaefer, F. Simkova, E. Stefanidis, C. J. Strazdins, V. Vande Walle, J. Schröder, C. Zurowska, A. Ekim, M. |
author_facet | Klaus, G. Watson, A. Edefonti, A. Fischbach, M. Rönnholm, K. Schaefer, F. Simkova, E. Stefanidis, C. J. Strazdins, V. Vande Walle, J. Schröder, C. Zurowska, A. Ekim, M. |
author_sort | Klaus, G. |
collection | PubMed |
description | Childhood renal osteodystrophy (ROD) is the consequence of disturbances of the calcium-regulating hormones vitamin D and parathyroid hormone (PTH) as well as of the somatotroph hormone axis associated with local modulation of bone and growth cartilage function. The resulting growth retardation and the potentially rapid onset of ROD in children are different from ROD in adults. The biochemical changes of ROD as well as its prevention and treatment affect calcium and phosphorus homeostasis and are directly associated with the development of cardiovascular disease in pediatric renal patients. The aims of the clinical and biochemical surveillance of pediatric patients with CRF or on dialysis are prevention of hyperphosphatemia, avoidance of hypercalcemia and keeping the calcium phosphorus product below 5 mmol(2)/l(2). The PTH levels should be within the normal range in chronic renal failure (CRF) and up to 2–3 times the upper limit of normal levels in dialysed children. Prevention of ROD is expected to result in improved growth and less vascular calcification. |
format | Text |
id | pubmed-1766475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-17664752007-01-11 Prevention and treatment of renal osteodystrophy in children on chronic renal failure: European guidelines Klaus, G. Watson, A. Edefonti, A. Fischbach, M. Rönnholm, K. Schaefer, F. Simkova, E. Stefanidis, C. J. Strazdins, V. Vande Walle, J. Schröder, C. Zurowska, A. Ekim, M. Pediatr Nephrol Editorial Commentary Childhood renal osteodystrophy (ROD) is the consequence of disturbances of the calcium-regulating hormones vitamin D and parathyroid hormone (PTH) as well as of the somatotroph hormone axis associated with local modulation of bone and growth cartilage function. The resulting growth retardation and the potentially rapid onset of ROD in children are different from ROD in adults. The biochemical changes of ROD as well as its prevention and treatment affect calcium and phosphorus homeostasis and are directly associated with the development of cardiovascular disease in pediatric renal patients. The aims of the clinical and biochemical surveillance of pediatric patients with CRF or on dialysis are prevention of hyperphosphatemia, avoidance of hypercalcemia and keeping the calcium phosphorus product below 5 mmol(2)/l(2). The PTH levels should be within the normal range in chronic renal failure (CRF) and up to 2–3 times the upper limit of normal levels in dialysed children. Prevention of ROD is expected to result in improved growth and less vascular calcification. Springer-Verlag 2005-10-25 2006-02 /pmc/articles/PMC1766475/ /pubmed/16247644 http://dx.doi.org/10.1007/s00467-005-2082-7 Text en © IPNA 2005 |
spellingShingle | Editorial Commentary Klaus, G. Watson, A. Edefonti, A. Fischbach, M. Rönnholm, K. Schaefer, F. Simkova, E. Stefanidis, C. J. Strazdins, V. Vande Walle, J. Schröder, C. Zurowska, A. Ekim, M. Prevention and treatment of renal osteodystrophy in children on chronic renal failure: European guidelines |
title | Prevention and treatment of renal osteodystrophy in children on chronic renal failure: European guidelines |
title_full | Prevention and treatment of renal osteodystrophy in children on chronic renal failure: European guidelines |
title_fullStr | Prevention and treatment of renal osteodystrophy in children on chronic renal failure: European guidelines |
title_full_unstemmed | Prevention and treatment of renal osteodystrophy in children on chronic renal failure: European guidelines |
title_short | Prevention and treatment of renal osteodystrophy in children on chronic renal failure: European guidelines |
title_sort | prevention and treatment of renal osteodystrophy in children on chronic renal failure: european guidelines |
topic | Editorial Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766475/ https://www.ncbi.nlm.nih.gov/pubmed/16247644 http://dx.doi.org/10.1007/s00467-005-2082-7 |
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