Serum calcitonin negative Medullary thyroid carcinoma

BACKGROUND: Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C cells which produce Calcitonin, a hormone which has an impact on calcium metabolism and represents the biochemical activity of MTC. In rare cases pre-operative serum ca...

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Autores principales: Sand, Michael, Gelos, Marcos, Sand, Daniel, Bechara, Falk G, Bonhag, Gerd, Welsing, Ellen, Mann, Benno
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769382/
https://www.ncbi.nlm.nih.gov/pubmed/17184544
http://dx.doi.org/10.1186/1477-7819-4-97
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author Sand, Michael
Gelos, Marcos
Sand, Daniel
Bechara, Falk G
Bonhag, Gerd
Welsing, Ellen
Mann, Benno
author_facet Sand, Michael
Gelos, Marcos
Sand, Daniel
Bechara, Falk G
Bonhag, Gerd
Welsing, Ellen
Mann, Benno
author_sort Sand, Michael
collection PubMed
description BACKGROUND: Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C cells which produce Calcitonin, a hormone which has an impact on calcium metabolism and represents the biochemical activity of MTC. In rare cases pre-operative serum calcitonin can be negative. CASE PRESENTATION: We report on a 73-year-old female patient with a rare case of a serum calcitonin negative medullary thyroid carcinoma who suffered fulminant post-operative course and died of multiple metastasis. CONCLUSION: This case shows that in very rare cases MTCs do not secrete calcitonin making diagnosis and tumour follow-up difficult. To this date, only few reports describing this combination of circumstances were found in the English literature.
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spelling pubmed-17693822007-01-13 Serum calcitonin negative Medullary thyroid carcinoma Sand, Michael Gelos, Marcos Sand, Daniel Bechara, Falk G Bonhag, Gerd Welsing, Ellen Mann, Benno World J Surg Oncol Case Report BACKGROUND: Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C cells which produce Calcitonin, a hormone which has an impact on calcium metabolism and represents the biochemical activity of MTC. In rare cases pre-operative serum calcitonin can be negative. CASE PRESENTATION: We report on a 73-year-old female patient with a rare case of a serum calcitonin negative medullary thyroid carcinoma who suffered fulminant post-operative course and died of multiple metastasis. CONCLUSION: This case shows that in very rare cases MTCs do not secrete calcitonin making diagnosis and tumour follow-up difficult. To this date, only few reports describing this combination of circumstances were found in the English literature. BioMed Central 2006-12-21 /pmc/articles/PMC1769382/ /pubmed/17184544 http://dx.doi.org/10.1186/1477-7819-4-97 Text en Copyright © 2006 Sand et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sand, Michael
Gelos, Marcos
Sand, Daniel
Bechara, Falk G
Bonhag, Gerd
Welsing, Ellen
Mann, Benno
Serum calcitonin negative Medullary thyroid carcinoma
title Serum calcitonin negative Medullary thyroid carcinoma
title_full Serum calcitonin negative Medullary thyroid carcinoma
title_fullStr Serum calcitonin negative Medullary thyroid carcinoma
title_full_unstemmed Serum calcitonin negative Medullary thyroid carcinoma
title_short Serum calcitonin negative Medullary thyroid carcinoma
title_sort serum calcitonin negative medullary thyroid carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769382/
https://www.ncbi.nlm.nih.gov/pubmed/17184544
http://dx.doi.org/10.1186/1477-7819-4-97
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AT bonhaggerd serumcalcitoninnegativemedullarythyroidcarcinoma
AT welsingellen serumcalcitoninnegativemedullarythyroidcarcinoma
AT mannbenno serumcalcitoninnegativemedullarythyroidcarcinoma

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